Abstract Library

#2852 Diagnostic Accuracy of Endoscopic Ultrasound-Fine Needle Aspiration (EUS-FNA) in the Evaluation of Pancreatic Neuroendocrine Neoplasms (PNEN) Grading

Introduction: Prognosis of pNENs depends on staging and grading, based on the cyto-histological Ki67 labelling; EUS-FNA is considered the gold standard technique to obtain it in pre-therapeutic setting

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Tacelli M

Authors: Tacelli M, Petrone M, Capurso G, Rossi G, Archibugi L,

Keywords: Pancreatic neuroendocrine neoplasms, Grading, EUS-FNA, Endoscopic ultrasound-Fine Needle Aspiration, Ki-67, WHO, misclassification,

#921 Combined Therapy with RAD001 e BEZ235 Overcomes Resistance of PET Cells to mTOR Inhibition

Introduction: Since the PI3K/Akt/mTOR proliferation axis is often deregulated in PETs, the mTORC1 complex inhibitor Everolimus (RAD001) represents an effective treatment for PETs. However, RAD001 leads to a re-activation of PI3K activity and phosphorylation of Akt, which may promote resistance to the treatment. Thus, direct inhibition of PI3K may represent a novel potential target for PETs.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Passacantilli I, Capurso G, Archibugi L, Calabretta S, Delle Fave G,

Keywords: mTOR, PI3K, resistance,