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Diagnostic Accuracy of Endoscopic Ultrasound-Fine Needle Aspiration (EUS-FNA) in the Evaluation of Pancreatic Neuroendocrine Neoplasms (PNEN) Grading


Introduction: Prognosis of pNENs depends on staging and grading, based on the cyto-histological Ki67 labelling; EUS-FNA is considered the gold standard technique to obtain it in pre-therapeutic setting

Aim(s): The aim was to establish diagnostic accuracy of preoperative EUS-FNA Ki67 evaluation in a cohort of pNEN patients

Materials and methods: This is a retrospective study from a prospectively collected database on patients who underwent surgery for pNENs from 2006 to 2019 and EUS-FNA Ki67 labelling.EUS-FNA and surgery Ki67 (eKi67 and sKi67) values and grading were compared and diagnostic accuracy of EUS-FNA was evaluated with sKi67 as gold standard. eKi67/sKi67 correlation was evaluated by Pearson’s index

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Tacelli M

Authors: Tacelli M, Petrone M, Capurso G, Rossi G, Archibugi L,

Keywords: Pancreatic neuroendocrine neoplasms, Grading, EUS-FNA, Endoscopic ultrasound-Fine Needle Aspiration, Ki-67, WHO, misclassification,

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