ENETS Research and Studies

ENETS encourages and supports non-commercial, multi-centric NET-related research within the ENETS community and the ENETS Centers of Excellence (CoE). This approach enables projects to collect the high-quality data required to answer clinical or translational questions in optimal timeframe.

Aims at a glance:

  • To increase collaboration within NET Centers/ ENETS CoE
  • To achieve a reliable amount of data answering NEN relevant scientific questions
  • To accelerate recruiting in prospective and retrospective clinical trials
  • To involve young researchers in collaborative research.

Below you will find information about current research projects and studies.

SurvivApp study publication

NEWS: ENETS is proud to announce that the ENETS-endorsed study SurvivApp entitled “hemicolectomy versus appendectomy for patients with appendiceal neuroendocrine tumours 1–2 cm in size: a retrospective, Europe-wide, pooled cohort study” has recently been published in Lancet Oncology.

ENETS congratulates and thanks all those who have been working on this study and is delighted to have been able to extend its support.

ASPEN trial publication

NEWS: ENETS is pleased to announce that the first interim analysis results from the ASPEN trial have been published British Journal of Surgery in late August 2022. Click below to read this open access article.

ENETS congratulates and thanks all those who have been working on this trial and is delighted to have been able to extend its support.

ENETS-supported Trials


Project title: "Asymptomatic Small Pancreatic Endocrine Neoplasms"

The aim of the study is to evaluate the most appropriate management of sporadic asymptomatic non-functioning pancreatic neuroendocrine neoplasms (NF-PNEN) ≤ 2 cm. P NF-PNEN management will be decided at the hospital and all therapeutics decision will be decided/coordinated by the treating physician.

Patients will be either submitted to surgical resection or to active surveillance.

Principal Investigator: IRCCS San Raffaele Hospital, Massimo Falconi


Project title: "Efficacy and Safety of Everolimus and (STZ-5FU) Given One Upfront the Other Upon Progression in Advanced Pancreatic Neuroendocrin Tumor (pNET)" (SEQTOR)

The ongoing trial (SEQTOR) is currently investigating the antiproliferative efficacy and safety of everolimus, followed by STZ/5‐FU in advanced pancreatic NET (pNET) in a crossover design upon progression.

Principal investigator: Medical Oncology Department, Duran i Reynals, Moisès Broggi & Costa de Ponent Hospitals, Institut Català d´Oncologia. Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Ramon Salazar

ENETS-endorsed Trials


Project title: "Distant Metastases and Long‐Term Survival After Complete Resection of Neuroendocrine Tumors of the Appendix" (SurvivApp)

The aim of the present project is to evaluate the frequency of distant metastases and clinically relevant relapse and mortality, respectively, of aNEN (Neuroendocrine Neoplasms of the Appendix) measuring 1 - 2 cm.

Principal investigator: Bern University Hospital, University of Bern, Reto Kaderli

Institutional Collaborative Trials


Project title: InterNaTional rEgistry oN Sars-cov-2 posItiVe nEuroendocrine neoplasm patients

This is a retrospective and prospective global collection of data through an international database to monitor NEN patients with SARS-CoV-2 infection.

Principal investigator: IEO Instituta Europeo di Oncologia, Nicola Fazio

Trials Supported by ENETS Grants

Endoscopic ultrasound-guided radiofrequency ablation for functional and non-functional Pan-NETS

Principal investigator: IRCCS Foundation University Hospital Policlinico A. Gemelli. and CERTT, Center for Endoscopic Research Therapeutics and Training, Catholic University, Rome, Italy, Alberto Larghi

Poor responders to Temozolomide in Pan-NETS

Project title: “Studying poor responders to Temozolomide (TMZ) in Pancreatic Neuroendocrine Tumours (PanNET); Unravelling mechanisms of primary resistance”.

Principal investigator: Institute of Pathology, University of Bern, Ilaria Marinoni

Role of Chromogranin A-derived fragments in Pan-NETS

Project title: "Role of Chromogranin A-derived fragments as pancreatic neuroendocrine tumor (PanNET) biomarkers and their involvement in PanNET biology."

Principal investigator: San Raffaele Scientific Institute, Experimental Oncology Division - Pancreatic Surgery Unit, Valentina Andreasi

Multiplex immunohistochemistry panel for pulmonary NETS

Project title: "Development of a multiplex immunohistochemistry panel to predict relapse free survival and treatment response on biopsy specimen of pulmonary carcinoid tumours".

Principle investigator: Maastricht University Medical Centre, Jules Derks

Multicentric morphological and molecular appraisal of GEP-NEN G3

Project title: "Multicentric morphological and molecular appraisal of GEP-NEN G3 with clinical correlations."

Principle investigator: University of Bergen, Halfdan Sorbye