Clinical Guidance & Standards of Care
ENETS develops multidisciplinary clinical guidance and standards of care to support evidence-based diagnosis, treatment, and follow-up in neuroendocrine neoplasms (NEN).
The publications provide up-to-date, practical recommendations reflecting current developments in diagnostics, systemic therapies, surgery, imaging, and long-term patient management.
ENETS Clinical Guidelines
ENETS Clinical Guidance papers are expert-led, question-based recommendations addressing key clinical challenges in the management of neuroendocrine neoplasms (NENs).
Developed by multidisciplinary specialists and published open access in the Journal of Neuroendocrinology, the series aims to support evidence-informed, best-practice decision-making in daily clinical care.
The publications are also compiled in the dedicated virtual issue ENETS clinical guidance on the management of NENs.
Current Guidance Papers
- Lung and thymic carcinoids
Journal of Neuroendocrinology 2026. DOI: 10.1111/jne.70174 - Management of well-differentiated small intestine neuroendocrine tumours
Journal of Neuroendocrinology 2024. DOI: 10.1111/jne.13423 - Nonfunctioning pancreatic neuroendocrine tumours
Journal of Neuroendocrinology 2023. DOI: 10.1111/jne.13343 - Appendiceal neuroendocrine tumours (aNET)
Journal of Neuroendocrinology 2023. DOI: 10.1111/jne.13332 - Functioning pancreatic NET syndromes
Journal of Neuroendocrinology 2023; 35:e13318. DOI: 10.1111/jne.13318 - Colorectal neuroendocrine tumours
Journal of Neuroendocrinology 2023; 35:e13309. DOI: 10.1111/jne.13309 - Gastroduodenal NETs G1–G3
Journal of Neuroendocrinology 2023. DOI: 10.1111/jne.13306 - Digestive neuroendocrine carcinoma
Journal of Neuroendocrinology 2023; 35:e13249. DOI: 10.1111/jne.13249 - Carcinoid syndrome and carcinoid heart disease
Journal of Neuroendocrinology 2022. DOI: 10.1111/jne.13146
ENETS Standards of Care
The ENETS Standards of Care publications provide multidisciplinary recommendations supporting the diagnosis, treatment, follow-up, and long-term management of neuroendocrine neoplasms (NEN).
Published in Neuroendocrinology, the ENETS 2017 Consensus Guidelines for the Diagnosis and Treatment of Neuroendocrine Tumors remain an important reference framework for clinical practice across multiple areas of NEN care.
- View the complete issue at Karger Publishers (Access is subject to the publisher’s policies.)
- Introduction - ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors
Pavel M, De Herder WW
Neuroendocrinology (2017) 105 (3): 193–195. DOI: 10.1159/000457957 - Pathology – Diagnosis and Prognostic Stratification
Perren A, Couvelard A, Scoazec J-Y, et al.
Neuroendocrinology (2017) 105 (3): 196–200. DOI: 10.1159/000457956 - Biochemical Markers
Oberg K, Couvelard A, Delle Fave G, et al.
Neuroendocrinology (2017) 105 (3): 201–211. DOI: 10.1159/000472254 - Radiological, Nuclear Medicine and Hybrid Imaging
Sundin A, Arnold R, Baudin E, et al.
Neuroendocrinology (2017) 105 (3): 212–244. DOI: 10.1159/000471879 - Pre- and Perioperative Therapy in Patients with Neuroendocrine Tumors
Kaltsas G, Caplin M, Davies P, et al.
Neuroendocrinology (2017) 105 (3): 245–254. DOI:10.1159/000461583 - Surgery for Small Intestinal and Pancreatic Neuroendocrine Tumours
Partelli S, Bartsch DK, Capdevila J, et al.
Neuroendocrinology (2017) 105(3):255-265. DOI: 10.1159/000464292 - Systemic Therapy – Biotherapy and Novel Targeted Agents
Pavel M, Valle JW, Eriksson B, et al.
Neuroendocrinology (2017) 105 (3): 266–280. DOI: 10.1159/000471880 - Systemic Therapy – Chemotherapy
Garcia-Carbonero R, Rinke A, Valle JW, et al.
Neuroendocrinology (2017) 105 (3): 281–294. DOI: 10.1159/000473892 - Peptide Receptor Radionuclide Therapy with Radiolabelled Somatostatin Analogues
Hicks RJ, Kwekkeboom DJ, Krenning E, et al.
Neuroendocrinology (2017) 105 (3): 295–309. DOI: 10.1159/000475526 - Follow-Up and Documentation
Knigge U, Capdevila J, Bartsch DK, et al.
Neuroendocrinology (2017) 105 (3): 310–319. DOI: 10.1159/000458155