ENETS Guidelines & Standards of Care

ENETS provides clinical guidance papers and standards of care to support the evidence-based diagnosis and management of neuroendocrine neoplasms (NEN).

These publications reflect current developments in diagnostics and treatment, including more individualised approaches, and offer structured, practice-oriented recommendations for clinical decision-making.

ENETS clinical guidance papers

ENETS is in the process of establishing question-based guidance papers, written by experts in the field. The purpose of these guidance papers is to collect the latest development and present comprehensive guidance to all our colleagues, helping them to establish a best-practice solution for their patients in their daily work.

Nine guidance papers, offering comprehensive insights into the management of various neuroendocrine tumours (NETs), have already been published in the Journal of Neuroendocrinology (open access).

We are happy to share with you the nine publications of the series:

Lung and thymic carcinoids – Published on 6 April 2026
Management of well-differentiated small intestine neuroendocrine tumours – Published on 8 July 2024
Nonfunctioning pancreatic neuroendocrine tumours – Published on 5 October 2023
Appendiceal neuroendocrine tumours (aNET) – Published on 16 August 2023
Functioning pancreatic NET syndromes – Published on 20 June 2023
Colorectal neuroendocrine tumours – Published on 2 June 2023
Gastroduodenal NETs G1-G3 – Published on 20 May 2023
Digestive neuroendocrine carcinoma – Published on 1 March 2023
Carcinoid syndrome and carcinoid heart disease – Published on 25 April 2022

They are also brought together in a dedicated virtual issue, ENETS clinical guidance on the management of neuroendocrine neoplasms (NENs), which compiles key recommendations across tumour types and clinical scenarios.

Explore the virtual issue at JNE:
https://onlinelibrary.wiley.com/doi/toc/10.1111/(ISSN)1365-2826.clinical-guidance

ENETS Standards of Care from 2017

ENETS 2017 Consensus Guidelines for the Diagnosis and Treatment of Neuroendocrine Tumors

Introduction - ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors
Pavel M, De Herder WW
ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Pathology – Diagnosis and Prognostic Stratification
Perren A, Couvelard A, Scoazec J-Y, Costa F, Borbath I, Delle Fave G, Gorbounova V, Gross D, Grossman A, Jensen RT, Kulke M, Oberg K, Rindi G, Sorbye H, Welin S; all other Antibes Consensus Conference participants.
ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Biochemical Markers
Oberg K, Couvelard A, Delle Fave G, Gross D, Grossman A, Jensen RT, Pape U-F, Perren A, Rindi G, Ruszniewski P, Scoazec J-Y, Welin S, Wiedenmann B, Ferone D; all other Antibes Consensus Conference participants.
ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Radiological, Nuclear Medicine and Hybrid Imaging
Sundin A, Arnold R, Baudin E, Cwikla JB, Eriksson B, Fanti S, Fazio N, Giammarile F, Hicks RJ, Kjaer A, Krenning E, Kwekkeboom D, Lombard-Bohas C, O’Connor JM, O’Toole D, Rockall A, Wiedenmann B, Valle JW, Vullierme M-P; all other Antibes Consensus Conference participants.
ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Pre- and Perioperative Therapy in Patients with Neuroendocrine Tumors
Kaltsas G, Caplin M, Davies P, Ferone D, Garcia-Carbonero R, Grozinsky-Glasberg S, Hörsch D, Tiensuu Janson E, Kianmanesh R, Kos-Kudla B, Pavel M, Rinke A, Falconi M, De Herder WW; all other Antibes Consensus Conference participants.
ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumours: Surgery for Small Intestinal and Pancreatic Neuroendocrine Tumours
Partelli S, Bartsch DK, Capdevila J, Chen J, Knigge U, Niederle B, Nieveen van Dijkum EJM, Pape U-F, Pascher A, Ramage JK, Reed N, Ruszniewski P, Scoazec J-Y, Toumpanakis C, Kianmanesh R, Falconi M; all other Antibes Consensus Conference participants.
ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms: Systemic Therapy – Biotherapy and Novel Targeted Agents
Pavel M, Valle JW, Eriksson B, Rinke A, Caplin M, Chen J, Costa F, Falkerby J, Fazio N, Gorbounova V, De Herder WW, Kulke M, Lombard-Bohas C, O’Connor JM, Sorbye H, Garcia-Carbonero R; all other Antibes Consensus Conference participants.
ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms: Systemic Therapy – Chemotherapy
Garcia-Carbonero R, Rinke A, Valle JW, Fazio N, Caplin M, Gorbounova V, O’Connor JM, Eriksson B, Sorbye H, Kulke M, Chen J, Falkerby J, Costa F, De Herder WW, Lombard-Bohas C, Pavel M; all other Antibes Consensus Conference participants.
ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms: Peptide Receptor Radionuclide Therapy with Radiolabelled Somatostatin Analogues
Hicks RJ, Kwekkeboom DJ, Krenning E, Bodei L, Grozinsky-Glasberg S, Arnold R, Borbath I, Cwikla JB, Toumpanakis C, Kaltsas G, Davies P, Hörsch D, Tiensuu Janson E, Ramage JK; all other Antibes Consensus Conference participants.
ENETS 2017 Consensus Recommendations for the Standards of Care in Neuroendocrine Neoplasms: Follow-Up and Documentation
Knigge U, Capdevila J, Bartsch DK, Baudin E, Falkerby J, Kianmanesh R, Kos-Kudla B, Niederle B, Nieveen van Dijkum EJM, O’Toole D, Pascher A, Reed N, Sundin A, Vullierme M-P; all other Antibes Consensus Conference participants.