ENETS Guidelines & Standards of Care

"Several guidelines on the management of neuroendocrine tumors have been published by expert national and international groups in recent years, however, a consensus on diagnosis and treatment is difficult to reach due to the limited evidence available in the literature. Nonetheless, novel diagnostic tools and therapies have emerged in the last 5 years as a substantial result of the continuous effort in the field. Indeed, slowly but constantly the neuroendocrine tumor world moves forward for the patients’ good."

Source: "ENETS 2011 Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Tumors: An Update", Authors: Ramon Salazar, Bertram Wiedenmann, Guido Rindi, Philippe Ruszniewski.

ENETS is currently working on new and updated guidelines in the field of Carcinoid Syndrome and Carcinoid Heart Disease(CS & CHD), and lung NET.

ENETS Guidelines

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ENETS Consensus Guidelines from 2016

These are the updated Guidelines for diagnosis and therapy of NEN from 2012.

1. ENETS 2016 Consensus Guidelines Update for Gastroduodenal Neuroendocrine Neoplasms
Delle Fave GF, O'Toole D, Sundin A, Taal B, Ferolla P, Ramage J, Ferone D, Ito T, Weber W, Zheng-Pei Z, De Herder WW, Pascher A, Ruszniewski P; all other Vienna Consensus Conference participants.

2. ENETS 2016 Consensus Guidelines Update for Neuroendocrine Neoplasm of the Jejunum and Ileum
Niederle B, Pape UF, Costa F, Gross D, Kelestimur F, Knigge U, Öberg K, Pavel M, Perren A, Toumpanakis C, O'Connor J, O'Toole D, Krenning E, Reed N, Kianmanesh R; all other Vienna Consensus Conference participants.

3. ENETS 2016 Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Tumours: An Update
O'Toole D, Kianmanesh R, Caplin M.

4. ENETS 2016 Consensus Guidelines Update for the Management of Functional p-NETs (F-p-NETs) and Non-Functional p-NETs (NF-p-NETs)
Falconi M, Eriksson B, Kaltsas G, Bartsch DK, Capdevila J, Caplin M, Kos-Kudla B, Kwekkeboom D, Rindi G, Klöppel G, Reed N, Kianmanesh R, Jensen RT; all other Vienna Consensus Conference participants.

5. ENETS 2016 Consensus Guidelines for High Grade Gastro-Entero-Pancreatic (GEP) Neuroendocrine Tumours and Neuroendocrine Carcinomas (NEC)
Garcia-Carbonero R, Sorbye H, Baudin E, Raymond E, Wiedenmann B, Niederle B, Sedlackova E, Toumpanakis C, Anlauf M, Cwikla J, Caplin M, O'Toole D, Perren A; all other Vienna Consensus Conference participants.

6. ENETS 2016 Consensus Guidelines Update for the Management of Distant Metastatic Disease of Intestinal, Pancreatic, Bronchial Neuroendocrine Neoplasms (NEN) and NEN of Unknown Primary Site
Pavel M, O'Toole D, Costa F, Capdevila J, Gross D, Kianmanesh R, Krenning E, Knigge U, Salazar R, Pape UF, Öberg K; all other Vienna Consensus Conference participants.

7. ENETS 2016 Consensus Guidelines Update for Colorectal Neuroendocrine Neoplasms (NEN)
Ramage J, De Herder WW, Delle Fave GF, Ferolla P, Ferone D, Ito T, Ruszniewski P, Sundin A, Weber W, Zheng-Pei Z, Taal B, Pascher A; all other Vienna Consensus Conference participants.

8. ENETS 2016 Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix (Excluding Goblet Cell Carcinomas)
Pape UF, Niederle B, Costa F, Gross D, Kelestimur F, Kianmanesh R, Knigge U, Öberg K, Pavel M, Perren A, Toumpanakis C, O'Connor J, Krenning E, Reed N, O'Toole D; all other Vienna Consensus Conference participants.

ENETS Standards of Care from 2017

ENETS 2017 Consensus Guidelines for the Diagnosis and Treatment of Neuroendocrine Tumors

1. Introduction - ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors
Pavel M, De Herder WW

2. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Pathology – Diagnosis and Prognostic Stratification
Perren A, Couvelard A, Scoazec J-Y, Costa F, Borbath I, Delle Fave G, Gorbounova V, Gross D, Grossman A, Jensen RT, Kulke M, Oberg K, Rindi G, Sorbye H, Welin S; all other Antibes Consensus Conference participants.

3. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Biochemical Markers
Oberg K, Couvelard A, Delle Fave G, Gross D, Grossman A, Jensen RT, Pape U-F, Perren A, Rindi G, Ruszniewski P, Scoazec J-Y, Welin S, Wiedenmann B, Ferone D; all other Antibes Consensus Conference participants.

4. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Radiological, Nuclear Medicine and Hybrid Imaging
Sundin A, Arnold R, Baudin E, Cwikla JB, Eriksson B, Fanti S, Fazio N, Giammarile F, Hicks RJ, Kjaer A, Krenning E, Kwekkeboom D, Lombard-Bohas C, O’Connor JM, O’Toole D, Rockall A, Wiedenmann B, Valle JW, Vullierme M-P; all other Antibes Consensus Conference participants.

5. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Pre- and Perioperative Therapy in Patients with Neuroendocrine Tumors
Kaltsas G, Caplin M, Davies P, Ferone D, Garcia-Carbonero R, Grozinsky-Glasberg S, Hörsch D, Tiensuu Janson E, Kianmanesh R, Kos-Kudla B, Pavel M, Rinke A, Falconi M, De Herder WW; all other Antibes Consensus Conference participants.

6. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumours: Surgery for Small Intestinal and Pancreatic Neuroendocrine Tumours
Partelli S, Bartsch DK, Capdevila J, Chen J, Knigge U, Niederle B, Nieveen van Dijkum EJM, Pape U-F, Pascher A, Ramage JK, Reed N, Ruszniewski P, Scoazec J-Y, Toumpanakis C, Kianmanesh R, Falconi M; all other Antibes Consensus Conference participants.

7. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms: Systemic Therapy – Biotherapy and Novel Targeted Agents
Pavel M, Valle JW, Eriksson B, Rinke A, Caplin M, Chen J, Costa F, Falkerby J, Fazio N, Gorbounova V, De Herder WW, Kulke M, Lombard-Bohas C, O’Connor JM, Sorbye H, Garcia-Carbonero R; all other Antibes Consensus Conference participants.

8. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms: Systemic Therapy – Chemotherapy
Garcia-Carbonero R, Rinke A, Valle JW, Fazio N, Caplin M, Gorbounova V, O’Connor JM, Eriksson B, Sorbye H, Kulke M, Chen J, Falkerby J, Costa F, De Herder WW, Lombard-Bohas C, Pavel M; all other Antibes Consensus Conference participants.

9. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms: Peptide Receptor Radionuclide Therapy with Radiolabelled Somatostatin Analogues
Hicks RJ, Kwekkeboom DJ, Krenning E, Bodei L, Grozinsky-Glasberg S, Arnold R, Borbath I, Cwikla JB, Toumpanakis C, Kaltsas G, Davies P, Hörsch D, Tiensuu Janson E, Ramage JK; all other Antibes Consensus Conference participants.

10. ENETS 2017 Consensus Recommendations for the Standards of Care in Neuroendocrine Neoplasms: Follow-Up and Documentation
Knigge U, Capdevila J, Bartsch DK, Baudin E, Falkerby J, Kianmanesh R, Kos-Kudla B, Niederle B, Nieveen van Dijkum EJM, O’Toole D, Pascher A, Reed N, Sundin A, Vullierme M-P; all other Antibes Consensus Conference participants.

ENETS Guidelines

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