ENETS Guidelines & Standards of Care

Over the past two decades, several guidelines for managing neuroendocrine tumours (NETs) have been published by ENETS and other expert groups and societies. Recent advancements in diagnostics and treatment have ushered in a shift towards personalised approaches and precision medicine. The expanded diagnostic spectrum, along with a growing array of therapeutic options, now enables clinicians to select the most promising individual treatments and optimise therapy sequences. These developments are transforming the landscape of NET management in clinical practice.

Recent ENETS guidance papers

ENETS is in the process of establishing question-based guidance papers, written by experts in the field. The purpose of these guidance papers is to collect the latest development and present comprehensive guidance to all our colleagues, helping them to establish a best-practice solution for their patients in their daily work.

Eight guidance papers, offering comprehensive insights into the management of various neuroendocrine tumours (NETs), have already been published in the Journal of Neuroendocrinology (open access).

We are happy to share with you the eight publications of the series:

- Management of well-differentiated small intestine neuroendocrine tumours – Published on 8 July 2024

- Nonfunctioning pancreatic neuroendocrine tumours – Published on 5 October 2023

- Appendiceal neuroendocrine tumours – Published on 16 August 2023

- Functioning pancreatic NET syndromes – Published on 20 June 2023

- Colorectal neuroendocrine tumours – Published on 2 June 2023

- Gastroduodenal NET G1-G3 – Published on 20 May 2023

- Digestive neuroendocrine carcinoma – Published on 1 March 2023

- ENETS guidance paper for carcinoid syndrome and carcinoid heart disease published on 25 April 2022

Stay informed with these key updates, reflecting the latest advances in the field of NETs.

ENETS Consensus Guidelines from 2016

These are the updated Guidelines for diagnosis and therapy of NEN from 2012.

1. ENETS 2016 Consensus Guidelines Update for Gastroduodenal Neuroendocrine Neoplasms
Delle Fave GF, O'Toole D, Sundin A, Taal B, Ferolla P, Ramage J, Ferone D, Ito T, Weber W, Zheng-Pei Z, De Herder WW, Pascher A, Ruszniewski P; all other Vienna Consensus Conference participants.

2. ENETS 2016 Consensus Guidelines Update for Neuroendocrine Neoplasm of the Jejunum and Ileum
Niederle B, Pape UF, Costa F, Gross D, Kelestimur F, Knigge U, Öberg K, Pavel M, Perren A, Toumpanakis C, O'Connor J, O'Toole D, Krenning E, Reed N, Kianmanesh R; all other Vienna Consensus Conference participants.

3. ENETS 2016 Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Tumours: An Update
O'Toole D, Kianmanesh R, Caplin M.

4. ENETS 2016 Consensus Guidelines Update for the Management of Functional p-NETs (F-p-NETs) and Non-Functional p-NETs (NF-p-NETs)
Falconi M, Eriksson B, Kaltsas G, Bartsch DK, Capdevila J, Caplin M, Kos-Kudla B, Kwekkeboom D, Rindi G, Klöppel G, Reed N, Kianmanesh R, Jensen RT; all other Vienna Consensus Conference participants.

5. ENETS 2016 Consensus Guidelines for High Grade Gastro-Entero-Pancreatic (GEP) Neuroendocrine Tumours and Neuroendocrine Carcinomas (NEC)
Garcia-Carbonero R, Sorbye H, Baudin E, Raymond E, Wiedenmann B, Niederle B, Sedlackova E, Toumpanakis C, Anlauf M, Cwikla J, Caplin M, O'Toole D, Perren A; all other Vienna Consensus Conference participants.

6. ENETS 2016 Consensus Guidelines Update for the Management of Distant Metastatic Disease of Intestinal, Pancreatic, Bronchial Neuroendocrine Neoplasms (NEN) and NEN of Unknown Primary Site
Pavel M, O'Toole D, Costa F, Capdevila J, Gross D, Kianmanesh R, Krenning E, Knigge U, Salazar R, Pape UF, Öberg K; all other Vienna Consensus Conference participants.

7. ENETS 2016 Consensus Guidelines Update for Colorectal Neuroendocrine Neoplasms (NEN)
Ramage J, De Herder WW, Delle Fave GF, Ferolla P, Ferone D, Ito T, Ruszniewski P, Sundin A, Weber W, Zheng-Pei Z, Taal B, Pascher A; all other Vienna Consensus Conference participants.

8. ENETS 2016 Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix (Excluding Goblet Cell Carcinomas)
Pape UF, Niederle B, Costa F, Gross D, Kelestimur F, Kianmanesh R, Knigge U, Öberg K, Pavel M, Perren A, Toumpanakis C, O'Connor J, Krenning E, Reed N, O'Toole D; all other Vienna Consensus Conference participants.

ENETS Standards of Care from 2017

ENETS 2017 Consensus Guidelines for the Diagnosis and Treatment of Neuroendocrine Tumors

1. Introduction - ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors
Pavel M, De Herder WW

2. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Pathology – Diagnosis and Prognostic Stratification
Perren A, Couvelard A, Scoazec J-Y, Costa F, Borbath I, Delle Fave G, Gorbounova V, Gross D, Grossman A, Jensen RT, Kulke M, Oberg K, Rindi G, Sorbye H, Welin S; all other Antibes Consensus Conference participants.

3. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Biochemical Markers
Oberg K, Couvelard A, Delle Fave G, Gross D, Grossman A, Jensen RT, Pape U-F, Perren A, Rindi G, Ruszniewski P, Scoazec J-Y, Welin S, Wiedenmann B, Ferone D; all other Antibes Consensus Conference participants.

4. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Radiological, Nuclear Medicine and Hybrid Imaging
Sundin A, Arnold R, Baudin E, Cwikla JB, Eriksson B, Fanti S, Fazio N, Giammarile F, Hicks RJ, Kjaer A, Krenning E, Kwekkeboom D, Lombard-Bohas C, O’Connor JM, O’Toole D, Rockall A, Wiedenmann B, Valle JW, Vullierme M-P; all other Antibes Consensus Conference participants.

5. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Pre- and Perioperative Therapy in Patients with Neuroendocrine Tumors
Kaltsas G, Caplin M, Davies P, Ferone D, Garcia-Carbonero R, Grozinsky-Glasberg S, Hörsch D, Tiensuu Janson E, Kianmanesh R, Kos-Kudla B, Pavel M, Rinke A, Falconi M, De Herder WW; all other Antibes Consensus Conference participants.

6. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Tumours: Surgery for Small Intestinal and Pancreatic Neuroendocrine Tumours
Partelli S, Bartsch DK, Capdevila J, Chen J, Knigge U, Niederle B, Nieveen van Dijkum EJM, Pape U-F, Pascher A, Ramage JK, Reed N, Ruszniewski P, Scoazec J-Y, Toumpanakis C, Kianmanesh R, Falconi M; all other Antibes Consensus Conference participants.

7. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms: Systemic Therapy – Biotherapy and Novel Targeted Agents
Pavel M, Valle JW, Eriksson B, Rinke A, Caplin M, Chen J, Costa F, Falkerby J, Fazio N, Gorbounova V, De Herder WW, Kulke M, Lombard-Bohas C, O’Connor JM, Sorbye H, Garcia-Carbonero R; all other Antibes Consensus Conference participants.

8. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms: Systemic Therapy – Chemotherapy
Garcia-Carbonero R, Rinke A, Valle JW, Fazio N, Caplin M, Gorbounova V, O’Connor JM, Eriksson B, Sorbye H, Kulke M, Chen J, Falkerby J, Costa F, De Herder WW, Lombard-Bohas C, Pavel M; all other Antibes Consensus Conference participants.

9. ENETS 2017 Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms: Peptide Receptor Radionuclide Therapy with Radiolabelled Somatostatin Analogues
Hicks RJ, Kwekkeboom DJ, Krenning E, Bodei L, Grozinsky-Glasberg S, Arnold R, Borbath I, Cwikla JB, Toumpanakis C, Kaltsas G, Davies P, Hörsch D, Tiensuu Janson E, Ramage JK; all other Antibes Consensus Conference participants.

10. ENETS 2017 Consensus Recommendations for the Standards of Care in Neuroendocrine Neoplasms: Follow-Up and Documentation
Knigge U, Capdevila J, Bartsch DK, Baudin E, Falkerby J, Kianmanesh R, Kos-Kudla B, Niederle B, Nieveen van Dijkum EJM, O’Toole D, Pascher A, Reed N, Sundin A, Vullierme M-P; all other Antibes Consensus Conference participants.