Abstract Library

#3864 Efficacy and safety of capecitabine and temozolomide (CAPTEM) in advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) – A systematic review and metanalysis

Introduction: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) are heterogeneous tumors, with multiple therapeutic options for advanced stages. The combination of capecitabine and temozolomide (CAPTEM) is increasingly used for advanced GEP-NEN, but evidence on results is sparse.

Conference:

Presenting Author: Tacelli M

Authors: Tacelli M, Massironi S, Gallo C, Bina N, Stornello C,

Keywords: chemotherapy, pfs, progression-free survival, adverse events,

#3857 The use of quantitative contrast-enhanced endoscopic ultrasound in the evaluation of pancreatic neuroendocrine tumors – Can we move from quality to quantity? A proof-of-concept study

Introduction: Contrast-enhanced EUS (CE-EUS) is a helpful tool for the diagnosis of pancreatic focal lesions, as pancreatic cancer (PC) and pancreatic neuroendocrine tumor (pNEN). The enhancement of the lesion after contrast medium injection is usually assessed qualitatively and arbitrarily by the endosonographer. Dedicated software has recently been developed to obtain an unbiased quantitative assessment using perfusion parameters.

Conference:

Presenting Author: Tacelli M

Authors: Tacelli M, Bina N, Capurso G, Zaccari P, Petrone M,

Keywords: CE-EUS, pNEN, artificial intelligence, pancreatic cancer, prediction,

#3586 Grading diagnostic accuracy of EUS Tissue Acquisition in pancreatic neuroendocrine tumors: A systematic review and meta-analysis

Introduction: Pancreatic neuroendocrine neoplasms (PanNENs), are a form of neoplasms arising from cells of the endocrine and nervous systems. Grading (G) is one of the most important decisional factor for therapy as is associated with prognosis, overall survival and disease free survival decrease. Endoscopic ultrasound fine needle-aspiration/biopsy (EUS-FNA/B) is the gold standard for diagnosing PanNENs and Ki67 evaluation, but data regarding accuracy and concordance with post-surgical histological examination are scanty and heterogeneous.

Conference:

Presenting Author:

Authors: Tacelli M, Bina N, Crinò S, Facciorusso A, Barresi L,

Keywords: endoscopic ultrasound, net, ki67, who, misclassification,

#3581 Pancreatic neuroendocrine tumors (PanNETs) vascularization: From “micro” to “macro”

Introduction: Density of microvessels in pancreatic neuroendocrine tumors (PanNETs) changes according to their biological behaviour. Differently from other non-neuroendocrine cancers, a low microvessel density (L-MVD) is associated with higher disease aggressiveness and poorer prognosis.

Conference:

Presenting Author:

Authors: Battistella A, Andreasi V, Palumbo D, Tacelli M, de Cobelli F,

Keywords: pancreatic neuroendocrine tumor, microvessel density, imaging, computed tomography, endoscopic ultrasound, vascularization, enhancement, washout,

#2852 Diagnostic Accuracy of Endoscopic Ultrasound-Fine Needle Aspiration (EUS-FNA) in the Evaluation of Pancreatic Neuroendocrine Neoplasms (PNEN) Grading

Introduction: Prognosis of pNENs depends on staging and grading, based on the cyto-histological Ki67 labelling; EUS-FNA is considered the gold standard technique to obtain it in pre-therapeutic setting

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Tacelli M

Authors: Tacelli M, Petrone M, Capurso G, Rossi G, Archibugi L,

Keywords: Pancreatic neuroendocrine neoplasms, Grading, EUS-FNA, Endoscopic ultrasound-Fine Needle Aspiration, Ki-67, WHO, misclassification,