Abstract Library

#4557 miR-1290 and miR-320c regulate cell proliferation and predict patient prognosis in neuroendocrine carcinomas

Introduction: The biology of neuroendocrine carcinomas (NECs) remains largely unknown, limiting the use of biomarkers for patient stratification and therapy response prediction in clinical practice.

Conference:

Presenting Author: Liverani C

Authors: Liverani C, Sgolacchia F, Bongiovanni A, Calabrese C, Vanni S,

Keywords: biomarker, miRNAs, neuroendocrine carcinoma,

#4481 Predicting peptide receptor radionuclide therapy (PRRT) response through the landscape of the immune microenvironment in neuroendocrine tumours

Introduction: Neuroendocrine tumours (NETs) often have poor prognosis upon metastasis. Peptide receptor radionuclide therapy (PRRT) is a novel treatment leveraging targeted cytotoxicity of radionuclides to efficiently address primary and metastatic tumours of NETs.

Conference:

Presenting Author: Yu J

Authors: Zeng Z, Lu M, Xie Q, Li J, Yang Z,

Keywords: peptide receptor radionuclide therapy, neuroendocrine tumour, tumour immune microenvironment, tumour response, therapeutic effect prediction,

#4379 Fully automated segmentation and lymph node metastasis prediction of non-functional pancreatic neuroendocrine tumours using deep learning

Introduction: Lymph node status is an important factor for the patients with NF-PanNETs with respect to surgical methods, prognosis, and recurrence. Our model serves as a non-invasive tool that supports clinical decision-making for precision surgical treatment in patients with NF-PanNETs.

Conference:

Presenting Author: Tang W

Authors: Tang W, Chen J,

Keywords: Non-functional pancreatic neuroendocrine tumour, deep learning, fully automated segmentation, imaging Informatics,

#4256 Epigenetic prediction of aging and metabolic traits provides insight into tumor biology in multi-focal ileal neuroendocrine tumors

Introduction: Approximately half of small intestinal neuroendocrine tumors (siNETs) are multifocal, and recent investigations into the genetic architecture of these tumors have found that they are not clonal. Due to the low mutational rate and slow growing nature of these small tumors, the ‘timing’ of the development of individual tumors has not been possible.

Conference:

Presenting Author:

Authors: Webster A, Makinen N, Ecker S, Beck S, Nakakura E,

Keywords: DNA methylation, Epigenetics, Multifocal Ileal Neuroendocrine Tumor, Multifocal Small Instestinal NET, Metabolic Traits,

#4217 Prediction of recurrence for grade 1-2 small bowel neuroendocrine neoplasms after curative-intended resection

Introduction: In patients with grade 1 to 2 small bowel neuroendocrine neoplasms (SB-NEN) reccurrence rates are reported up to 50%. No prediction tools exist yet to identify patients at high-risk for recurrence in SB-NENs.

Conference:

Presenting Author:

Authors: Erdmann F, Addeo P, Falconi M, Hennings J, Makay �,

Keywords: small bowel neuroendocrine neoplasm, recurrence, nomogram,