Abstract Library

#1465 Assocation Between miRNAs and HDACs in Pancreatic Neuroendocrine Tumors

Introduction: Epigenetic factors are essentially involved in carcinogenesis, tumor promotion and chemo resistance with their major key players of miRNAs and histone deacetylases (HDACs). As shown by own theoretical databank analysis, the crosstalk between miRNAs and HDACs are relevant in different human chronic diseases and cancerogenic pathways.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Swierczynski S, Klieser E, Urbas R, Stättner S, Primavesi F,

Keywords: Epigenetics, miRNA, histone deacetylases, pancreatic neuroendocrine tumor,

#1227 Molecular Profiling of Small Intestinal Neuroendocrine Tumours (SINETs)

Introduction: Aberrant DNA methylation plays an role in the pathogenesis of many cancers, however little is known about its role in SINET development.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Thirlwell C

Authors: Karpathakis A, Feber A, Morris T, Dibra H, Pipinikas C,

Keywords: Epigenetics, methylation, GIPR, biomarker,

#976 Upregulation of Somatostatin Receptor Type 2 Expression in Neuroendocrine Tumors by Epigenetic Modulation

Introduction: The somatostatin receptor type 2 (sst2) is a target for treatment of neuroendocrine tumors (NETs). However, epigenetic mechanisms might account for the high variability in sst2 expression and treatment response between patients.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Veenstra M, Van Koetsveld P, Farrell W, Dogan F, Waaijers A,

Keywords: GEP-NET, sst2, epigenetics,

#969 Identification of Hypoxia Induced Epigenetic Changes in the Development of Pancreatic Neuroendocrine Tumors

Introduction: In VHL syndrome, pancreatic NETs develop through bi-allelic inactivation of VHL with subsequent HIF pathway activation. This also occurs in sporadic pancreatic NETs.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Dibra H, Connor T, Ashcroft M, Maxwell P, Thirlwell C,

Keywords: neuroendocrine, von Hippel-Lindau (VHL), hypoxia, epigenetics,

#936 Promoter Hypermethylation at RASSF1 is a Feature of Small Intestinal Neuroendocrine Tumors

Introduction: Promoter hypermethylation of RASSF1 has been reported in many tumor types.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Karpathakis A

Authors: Karpathakis A, Dibra H, Morris T, Feber A, Mandair D,

Keywords: Epigenetics, methylation, RASSF1,