Abstract Library

#2022 CXCR4 Expression on Circulating Tumor Cells (CTCs) and Their Association with Bone Metastases in Patients with Neuroendocrine Tumors (NET)

Introduction: Bone metastases have been described in up to 32% of NET patients and are associated with a worse clinical outcome. Overexpression of CXCR4 in primary tumors appears predictive of skeletal involvement.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Rizzo F, Vesely C, Childs A, Mandair D, Khan M,

Keywords: CTC, CXCR4, bone,

#1698 Assessment of Small Intestinal Bacterial Overgrowth (SIBO) in NET Patients

Introduction: SIBO is not uncommon in NETs. Hydrogen Breath testing (HBT) using glucose may be more sensitive to proximal SIBO as glucose rarely reaches the colon. Many NET patients are likely to have distal SIBO however, as factors such as ileocecal valve removal apparently increase distal SIBO risk. Thus glucose BT alone may limit sensitivity for detecting SIBO in some NET diagnoses.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Whyand T, Koffas A, Toumpanakis C, Mandair D, Caplin M,

Keywords: nets, sibo, dysbiosis, ,

#982 Rectal Neuroendocrine Tumors: A Review of Clinical Outcomes

Introduction: Rectal neuroendocrine tumors (rNETs) are increasing in incidence, with more found incidentally on routine colonoscopy.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Naik K, Rossi R, Mandair D, Toumpanakis C, Caplin M,

Keywords: rectal NETs,

#936 Promoter Hypermethylation at RASSF1 is a Feature of Small Intestinal Neuroendocrine Tumors

Introduction: Promoter hypermethylation of RASSF1 has been reported in many tumor types.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Karpathakis A

Authors: Karpathakis A, Dibra H, Morris T, Feber A, Mandair D,

Keywords: Epigenetics, methylation, RASSF1,

#922 Comparison of the Novel Cell Detector Method with Cell Search Technology in the Isolation of Circulating Tumor Cells in Neuroendocrine Tumors

Introduction: Circulating Tumor Cells (CTCs) have been detected in patients with neuroendocrine tumors (NET) using the CellSearch platform. Their presence is associated with a worse clinical outcome but less than 50% patients have detectable cells. The GILUPI Cell Detector is an EpCAM coated wire that is inserted into a vein and has been developed to increase capture of CTCs.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Mandair D, Ensell L, Vesely C, Lowe H, Caplin M,

Keywords: CTCs, EpCAM, neuroendocrine,