Abstract Library

#4180 Non-functional alpha-cell hyperplasia with glucagonoma: A case report

Introduction: Alpha-cell hyperplasia(ACH) is a rare pancreatic endocrine condition. Clinically, 3 types have been described: functional ACH (nonglucagonoma hyperglucagonemic glucagonoma syndrome), reactive ACH (secondary to defective glucagon signalling) and non-functional ACH. Few cases of ACH and non-functional pancreatic neuroendocrine tumors (pNET) have been reported and its aetiology remains poorly understood.

Conference:

Presenting Author: Santos A

Authors: Cidade Rodrigues C, Santos A, Calheiros R, Santos S, Matos C,

Keywords: alpha-cell hyperplasia, diabetes, glucagon, pancreas, neuroendocrine tumor,

#3734 Treatment outcomes in patients with localized and advanced glucagonomas – A case series

Introduction: Glucagonomas are rare functional pancreatic neuroendocrine tumors, which are often metastatic at diagnosis. Due to their low prevalence, the effectiveness of available treatment modalities remains unclear.

Conference:

Presenting Author: Armeni E

Authors: Porto J, Alexander B, Armeni E, Hesketh R, Mandair D,

Keywords: glucagonoma, treatment lines, progression-free survival, overall survival,

#3678 Complete remission of Necrolytic Migratory Erythema related to glucagonoma under octreotide therapy

Introduction: Glucagonomas are rare neuroendocrine tumors (NETs), generally diagnosed with locoregional involvement; it has heterogeneous survival with therapeutic approaches ranging from the use of somatostatin analogues, and cytoreductive surgery to PRRT.

Conference:

Presenting Author:

Authors: González Devia D, Rozo-Paz G, Chalela-Mantilla J, Aguirre Matallana D, Arias Amézquita F,

Keywords: Glucagonoma, Migratory necrolytic erythema, Octreotide, Overall survival, Neuroendocrine tumor,

#3656 Glucagonomas – Characteristics and treatment options based on a French multicenter cohort study

Introduction: Glucagonoma is a rare functional pancreatic neuroendocrine tumor (pNET).

Conference:

Presenting Author:

Authors: Perrier M, Brugel M, Walter T, Goichot B, Lièvre A,

Keywords: glucagonoma, neuroendocrine neoplasm, pancreas, necrolytic migratory erythema,

#3369 Evaluating the significance of Chromogranin A and Synaptophysin in Pancreatic Neuroendocrine Tumors. A road towards finding independent biomarkers

Introduction: Chromogranin A (CgA) and Synaptophysin(SPY) are most commonly used immunohistochemical markers of Neuroendocrine cells and tumors. CgA is a marker for neuroendocrine secretory granules of gastrin and four pancreatic hormones and gastrin while SPY is a marker for synaptic vesicles in neuroendocrine cells.

Conference:

Presenting Author: Fatima A

Authors: Fatima A,

Keywords: chromogranin A, Synaptophysin, prognostic marker, pancreatic neuroendocrine, insulinoma,