Evaluating the significance of Chromogranin A and Synaptophysin in Pancreatic Neuroendocrine Tumors. A road towards finding independent biomarkers

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Introduction: Chromogranin A (CgA) and Synaptophysin(SPY) are most commonly used immunohistochemical markers of Neuroendocrine cells and tumors. CgA is a marker for neuroendocrine secretory granules of gastrin and four pancreatic hormones and gastrin while SPY is a marker for synaptic vesicles in neuroendocrine cells.

Aim(s): We aim to find the significance of Chromogranin A and Synaptophysin in Pancreatic Neuroendocrine Tumors.

Materials and methods: The study was done retrospectively and total thirty cases were included consisting of 12 insulinomas, 7 gastrinomas, 4 pancreatic polypeptidomas, 3 non-functioning tumors and 1 glucagonoma. All tissues were immunostained for four pancreatic hormones, gastrin, CgA, and SPY.

Conference:

Presenting Author: Fatima A

Authors: Fatima A,

Keywords: chromogranin A, Synaptophysin, prognostic marker, pancreatic neuroendocrine, insulinoma,