Non-functional alpha-cell hyperplasia with glucagonoma: A case report

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Introduction: Alpha-cell hyperplasia(ACH) is a rare pancreatic endocrine condition. Clinically, 3 types have been described: functional ACH (nonglucagonoma hyperglucagonemic glucagonoma syndrome), reactive ACH (secondary to defective glucagon signalling) and non-functional ACH. Few cases of ACH and non-functional pancreatic neuroendocrine tumors (pNET) have been reported and its aetiology remains poorly understood.

Aim(s): A case report of non-functional ACH with glucagonoma is herein presented.

Materials and methods: A 72-years-old male was referred to our institution for a 2cm single pNET incidentally found during imaging workout for acute cholecystitis. Patient's past medical history included type 2 diabetes diagnosed 12 years earlier, for which he was under metformin, dapagliflozin and semaglutide. The pNET was clinically non-functional, with normal hormone levels apart from mildly elevated glucagon 217pg/ml(<209). PET/CT-68Ga-SSTR only showed positive uptake in the pancreatic tail (SUVmax 11.45) and therefore the patient underwent a caudal pancreatectomy.

Conference:

Presenting Author: Santos A

Authors: Cidade Rodrigues C, Santos A, Calheiros R, Santos S, Matos C,

Keywords: alpha-cell hyperplasia, diabetes, glucagon, pancreas, neuroendocrine tumor,