#3056
Multi-Omic Characterization and Evolution of Neuroendocrine Neoplasm Organoids
Introduction:
Molecular characterizations of neuroendocrine neoplasm (NENs) have unveiled candidate alterations associated with aggressiveness and suggested that the molecular link between neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) might be subtler than initially thought. For example, we have recently unveiled a new entity of pulmonary carcinoids (supra-carcinoids) with carcinoid-like morphology yet the molecular and clinical features of large cell neuroendocrine carcinoma (LCNEC). Testing hypotheses to explain aggressiveness and the possibility of progression or transition from NET to NEC through the accumulation of genetic anomalies requires in vitro and in vivo experimental models.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Foll M
Authors:
Alcala N,
Dayton T,
Mangiante L,
Delhomme T,
Tabone-Egling S,
Keywords:
organoids,
omics,
evolution,
lung,
pancreas,
bioinformatics,
#3052
Unique Metastatic Patterns in Neuroendocrine Neoplasms of Different Primary Origin
Introduction:
Neuroendocrine neoplasms (NEN) can originate in different organs, e.g. in the gastro-enteric tract (GE), pancreas (P) or lung (L). Despite similarities in clinical and pathological characteristics in tumors of another origin, differences also exist. This might apply to metastatic patterns as well, but only limited data is available so far.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Authors:
Hermans B,
Derks J,
Willems A,
Bilochvostenko M,
Bayazit S,
Keywords:
neuroendocrine neoplasms,
stage IV,
metastases,
survival,
epidemiology,
#2986
Characterization of 142 Human Pancreatic Neuroendocrine Tumors: ATRX and DAXX Correlation with Clinical-Pathological Data
Introduction:
Pancreatic neuroendocrine tumors (PNETs) are rare and heterogeneous neoplasms with a 10-year survival rate less than 30%. Up to 43% of them are driven by inactivating mutations in ATRX or DAXX. These are important players at chromatin remodeling, that when mutated prone cancer cells to initiate the alternative lengthening of telomeres (ALT). ALT phenotype correlates with in situ loss of expression of the proteins ATRX or DAXX and can be corroborated by telomere-FISH.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Authors:
Gaspar T,
Pinheiro J,
Canberk S,
İnce �,
Tokat F,
Keywords:
pancreas,
pancreatic neuroendocrine tumors,
PNETs,
ATRX,
DAXX,
ALT,
mosaic,
#2957
New Evidence of Emerging Nodal Metastasis in Staging System after Surgical pNET Resection as Predictive Factor for Recurrence. Result from Monocentric Retrospective Series
Introduction:
New evidence is emerging of the role of pNETs lymphatic metastasis in terms of Oncological Outcomes. A specific staging classification is not actually available.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Mastrangelo l
Authors:
Mastrangelo L,
Romboli A,
Masetti M,
Zanello M,
Cipressi C,
Keywords:
lymph node status,
neuroendocrine tumor,
pancreas,
prognosis,
surgery,