Investigating the dual role of SNW1 in splicing and transcription to understand pancreatic neuroendocrine tumour progression

#4568

Introduction: Pancreatic neuroendocrine tumours (PanNETs) are classified into grades (G1-G3) based on mitotic rate, with higher grades exhibiting increased dedifferentiation and invasiveness. Despite the clinical significance of PanNETs progression, the underlying mechanisms remain largely unexplored. We have previously reported that altered alternative splicing plays an essential role in PanNETs progression, where SNW1, a key regulator of splicing and transcription, was found to be overexpressed in tumour tissue, correlating with higher grade and recurrence risk.

Aim(s): Hence, our hypothesis is that SNW1 could potentially drive PanNET progression by its dual role on transcription and splicing.

Materials and methods: To further assess the role of SNW1 in PanNETs, we modulated its expression using RNA interference to evaluate its effects on cell cycle, pluripotency, and differentiation.

Conference:

Presenting Author: González-Pérez C

Authors: González-Pérez C, Simón-Lesnyak M, Blázquez-Encinas R, García Vioque V, Moreno Montilla M,

Keywords: pancreas, neuroendocrine tumour, progression, SNW1, splicing,