Abstract Library
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ENETS Abstract Search
Introduction: There is increasing evidence that alterations in alternative splicing are linked to key tumor features in different cancers. Besides mutations, dysregulation of the splicing machinery would represent the main underlying cause for these alterations. Indeed, splicing dysregulation is emerging as a novel, transversal cancer hallmark, due to its association with multiple dysfunctions in tumor cells.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Alors-Pérez E
Authors: Alors-Pérez E, Pedraza-Arévalo S, Vázquez-Borrego M, Blázquez-Encinas R, Herrera-Martínez A,
Keywords: PanNET, CELF4, splicing, aggressiveness, pituitary tumors,
#3053 The Splicing Machinery Is Dysregulated in Low Grade Pulmonary Neuroendocrine Tumors
Introduction: Alternative splicing dysregulation is increasingly regarded as a novel cancer hallmark influencing all key tumor features. We have shown that neuroendocrine tumors (NETs) overexpress aberrantly spliced variants of neuropeptides and receptors that increase tumor malignancy. More recently, we discovered that the splicing machinery is dysregulated in pituitary and pancreatic NETs. To date, the status of this machinery in low grade pulmonary NETs is largely unknown.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Blázquez-Encinas R
Authors: Blázquez-Encinas R, Caro M, Pedraza-Arévalo S, Alors-Pérez E, Herrera-Martínez A,
Keywords: low grade pulmonary NETs, splicing, splicing machinery, malignancy,
Introduction: Hypoxia in human tumours is associated with a poor prognosis and is characterized by the stabilization of HIF1α, upregulation of VEGF, and a high microvessel density (MVD). Interestingly, although pancreatic neuroendocrine tumours (pNETS) showing hypoxia signalling also have a poor prognosis, they paradoxically display a low MVD. We hypothesized that this paradoxon might be explained by alternative splicing of VEGF.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Schmitt A
Authors: Marinoni I, Naim S, Centeno I, Perren A, Schmitt A,
Introduction: Sst5TMD4, which is derived from a non-canonical splicing process of sst5 receptor, is overexpressed in several endocrine tumors and associated with a worse prognosis.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author:
Authors: Diaz Perez A, Martínez-Fuentes A, García-Carbonero R, Luque R, Jimenez-Fonseca P,
Keywords: somatostatin receptor, neuroendocrine tumors,
Introduction: Insulin-like growth factor-I (IGF-I) has a key role in cell proliferation, differentiation, migration, and survival. Different IGF-I mRNA transcripts, such as IGF-IEc (mechano growth factor, MGF), are produced by alternative splicing. MGF has been implicated in muscle regeneration process as well as in the pathophysiology of various types of cancer.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Alexandraki K
Authors: Alexandraki K, Philippou A, Boutzios G, Theohari I, Moschouris P,
Keywords: Neuroendocrine neoplasms, MGF, IGF-IEc, ki-67,