Abstract Library

#1850 Influence of VEGF Splicing on Microvessel Density and Architecture in Pancreatic Neuroendocrine Tumours

Introduction: Hypoxia in human tumours is associated with a poor prognosis and is characterized by the stabilization of HIF1α, upregulation of VEGF, and a high microvessel density (MVD). Interestingly, although pancreatic neuroendocrine tumours (pNETS) showing hypoxia signalling also have a poor prognosis, they paradoxically display a low MVD. We hypothesized that this paradoxon might be explained by alternative splicing of VEGF.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Schmitt A

Authors: Marinoni I, Naim S, Centeno I, Perren A, Schmitt A,

Keywords: pNET, VEGF,

#502 Bifunctional ShRNAimPDX-1 Therapy Prevents Hypoglycemic Death From Insulinoma in Mice

Introduction: PDX-1 is a novel molecular target for insulinoma. Bi-functional shRNAi platform has been developed that results in a more effective targeted gene knockdown.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Liu S, Wang Z, Shahi K, Rao D, Zhou G,

Keywords: PDX-1, bi-shRNAi, insulinoma, target,