Abstract Library

#4620 Impact of the extent of surgical resection on the development of post-operative diabetes in patients undergoing distal pancreatectomy for non-functioning pancreatic neuroendocrine tumours (NF-PanNET)

Introduction: Pancreatic neuroendocrine tumours (PanNETs) are often indolent neoplasms. Surgery is the primary curative approach for localised non-functioning (NF) PanNETs, but it poses a risk of long-term complications, such as diabetes, impacting quality of life.

Conference:

Presenting Author:

Authors: Battistella A, Partelli S, Guccinelli E, Prato F, Andreasi V,

Keywords: Pan NET, distal pancreatectomy, post-operative diabetes, surgical extension,

#4583 Improved assessment of gene rearrangements by targeting non-coding DNA regions in patients diagnosed with pancreatic neuroendocrine neoplasms

Introduction: Whole-genome sequencing projects documented the heterogeneity of pancreatic neuroendocrine neoplasms (PanNEN), while showing that few core pathways are consistently affected in their tumorigenesis. Comprehensive genomic profiling (CGP) of real-world cases is expected to recapitulate such heterogeneity for patient stratification and to inform precision therapy. While coding DNA is the focus of current CGP panels, the potential of targeting non-coding DNA (ncDNA) to improve structural variants detection has not been widely explored in this context.

Conference:

Presenting Author: Agnoletto C

Authors: Agnoletto C, Trevisani E, Borghesani M, Landoni L, Luchini C,

Keywords: neuroendocrine, non-coding DNAs, structural variants, clinical relevance, CGP panel,

#4216 Immunohistochemical analysis for galectin-3 and outcomes in medullary thyroid cancer

Introduction: Galectin-3 (Gal-3) is a beta-galactoside involved in multiple biological and pathological processes including growth and differentiation, cellular adhesion and transformation, and metastatic potential.

Conference:

Presenting Author: Raia S

Authors: Raia S, Chiloiro S, Giampietro A, Lugli F, Maratta M,

Keywords: Thyroid, MTC, Galectine3,

#4076 Machine learning model: Predicting prognosis in neuroendocrine tumors

Introduction: Neuroendocrine tumors (NETs) have a heterogeneous clinical course. Even with similar Ki-67 proliferative index/morphology, the course varies in patients with similar pathological characterization.

Conference:

Presenting Author:

Authors: Varghese D, Naimian A, Yazdian P, Lokre O, Perk T,

Keywords: Neuroendocrine tumor, artificial intelligence, DOTATATE scan,

#4069 Impact of nutritional status in the quality of life (QoL) of patients with advanced gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) in Spain: NUTRIGETNE Study

Introduction: Prevalence of malnutrition and sarcopenia is high among patients with advanced GEP-NENs and may significantly decrease response to therapy and impair QoL.

Conference:

Presenting Author:

Authors: Del Olmo-García M, Garcia-Carbonero R, Hernando J, Pérez-Wert P, Suarez Gutiérrez L,

Keywords: nutritional status, Gastroenteropancreatic, Neuroendocrine neoplasm, Sarcopenia, Malnutrition,