Abstract Library

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ENETS Abstract Search

#1207 A Novel MEN1 Gene Variant in a Sporadic Case of Multiple Endocrine Neoplasia Type 1

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by the occurrence of hyperparathyroidism, pituitary adenomas and duodeno-pancreatic neuroendocrine tumours (NETs). Germline mutations of the MEN1 gene are identified in up to 87% of MEN1 families and 82% of isolated MEN1 cases.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Iacovazzo D

Authors: Iacovazzo D, Piacentini S, Lugli F, Bianchi A, Gabrovska P,

Keywords: MEN1, mutation, gastric carcinoid,

#1206 Two Cases of Ectopic ACTH-Secreting Neoplasm of Occult Origin Becoming Overt After Bilateral Adrenalectomy

Introduction: Cushing's syndrome (CS) is an endocrine disorder associated with serious consequences if not adequately treated. Nearly 80% of the cases of endogenous hypercortisolism are adrenocorticotropic hormone (ACTH) dependent, the ACTH source being pituitary in about 70-80% and ectopic in 10-15%. The ACTH source may remain occult in few cases for many years in spite of extensive investigations.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Piacentini S, Iacovazzo D, Lugli F, Giampietro A, Bianchi A,

Keywords: Cushing's syndrome, Ectopic ACTH, Bilateral adrenalectomy,

#1013 Evaluation of VEGF and Endocan/ESM-1 Expression in pNETs and Correlation with Ki-67 and Prognosis

Introduction: Endocan has been reported as specific of endothelial tumor cells and was shown to be expressed by tip cells during the angiogenesis process.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Lugli F

Authors: Lugli F, Iacovazzo D, Lanza P, Inzani F, De Waure C,

Keywords: GEP-NET, Endocan, VEGF,

#1012 Efficacy of Lanreotide Autogel in MEN1-Related Gastrinoma: A Case Series

Introduction: GEP NETs, especially gastrinomas, occur in 40-70% of MEN1 patients and represent the main cause of death in these patients.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Iacovazzo D

Authors: Iacovazzo D, Lugli F, Bianchi A, Capoluongo E, Lucci-Cordisco E,

Keywords: MEN1, SSA, gastrin,

#765 Everolimus Treatment in a Series of Patients with Advanced Neuroendocrine Tumors

Introduction: Everolimus is an oral mTOR inhibitor that exerts antineoplastic effects inhibiting cell proliferation, survival and angiogenesis. Its activity in advanced neuroendocrine tumors (NETs) has been demonstrated in controlled trials and everolimus was approved by the FDA for the treatment of progressive, advanced pNETs in May 2011.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Plastino F, Iacovazzo D, Schinzari G, Barile R, Lugli F,

Keywords: everolimus, prrt,