Abstract Library

#2955 Development of an EORTC Quality of Life Questionnaire for Patients with Pancreatic Neuroendocrine Tumours: Phases 1-3

Introduction: Measuring quality of life (QoL) in Pancreatic Neuroendocrine Tumours (pNET) involves assessing issues from symptoms, disease and treatment. The validated gastrointestinal NETs module (EORTC QLQ-GINET21) is used with EORTC QLQ-C30 but there are concerns it inadequately measures QoL in pNET.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Friend E, Gray D, Fernández Ortega P, McNamara M, Kaltsas G,

Keywords: research, neuroendocrine, insulinoma, gastrinoma, non-functioning, VIPoma, Glucagonoma, questionnaire, quality of life,

#2775 Glucagonoma: Still a Misleading Disease and the Importance of Multidisciplinary Neuroendocrine Tumor Board

Introduction: Glucagonoma is a rare neuroendocrine tumor (NET) of the pancreatic alpha cells that results in the overproduction of the hormone glucagon. This entity is typically associated with a rash called necrolytic migratory erythema, weight loss and diabetes.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Parlagreco E

Authors: Parlagreco E, La Salvia A, Persano I, Pia A, Scagliotti G,

Keywords: glucagonoma, necrolytic migratory erithema, diagnostic delay, patient’s quality of life,

#1936 The Expression of IGF Signaling Pathway Genes Is Frequently Elevated in Pancreatic Neuroendocrine Tumors, but Is Downregulated in Metastases

Introduction: Studies have implicated EGFR, IGF and mTOR signaling pathways in the regulation of pNET growth. Interpretation of these studies is complex due to tumor subtype heterogeneity and differences in molecular analysis.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Speel E

Authors: Henfling M, Versleijen-Jonkers Y, Starke A, Riedl R, Sprij-Mooij D,

Keywords: , ,

#1511 MEN1-related Glucagonomatosis Incidentally Revealed During Management of Recurrent Intestinal Obstruction Following Surgery for Crohn’s Disease

Introduction: Glucagonomas may present with varied intestinal symptoms,weight loss,diabetes and a typical rash. MEN1 related glucagonomas are extremely rare.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Malczewska A

Authors: Malczewska A, Vlavianos P, Faiz O, Gabe S, Abraham R,

Keywords: MEN1, glucagonoma,

#1160 Exclusive Hotspot Mutation of YY1 Gene in Insulinomas and Extensive Mutation of DAXX in PNETs

Introduction: Somatic mutation of YY1 was shown in sporadic insulinoma, the main type of functional PNET. DAXX mutation occurred mainly in NF-PNET. However, YY1 and DAXX mutations in non-insulinomas and insulinomas, respectively, have not been well elucidated.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Song Y

Authors: Song Y, Qiao X, Bai C, Lu C, Chen J,

Keywords: YY1,daxx,mutation,PNET,