Abstract Library

#4090 Octreotide infusion pump in patients with functional neuroendocrine tumors and refractory hormonal syndromes

Introduction: In patients with metastatic functional neuroendocrine tumors (NETs), symptoms are, sometimes, not adequately controlled with long-acting somatostatin analogues (LASSAs), so patients need to use boost subcutaneous (sc) octreotide injections (inj) daily. However, this approach is not always effective and convenient for the patients.

Conference:

Presenting Author: Thuringer J

Authors: Thuringer J, Parker G, Sarma A, Hayes A, Mandair D,

Keywords: carcinoid syndrome, VIPoma, Octreotide, pump, refractory, subcutaneous,

#3995 Pelvic metastases in patients with neuroendocrine tumors: A rare site of metastases

Introduction: Pelvic metastases (PMs) in patients with neuroendocrine tumors (NETs) are rare and develop predominately in women with small intestinal NETs (Si-NETs). The characteristics of NET related PMs and the efficacy of different management options have been poorly investigated.

Conference:

Presenting Author:

Authors: Thuringer J, Tsoli M, Parker G, Sarma A, Panagaki M,

Keywords: pelvic metastases, prognosis, oophorectomy, PRRT,

#2297 Merkel Cell Carcinomas in New Zealand: Virus or Ultra Violet?

Introduction: Merkel Cell Carcinoma (MCC) is a rare Neuroendocrine skin tumour. MCC behavior is more aggressive than the more common Melanoma, with treatments often restricted to surgery or radiotherapy, although immunotherapy holds promise overseas. In 2008, a USA study identified an oncogenic polyomavirus (MCPyV) present in eight of ten tested MCC tumours. Studies from across Europe and the USA confirmed MCPyV presence in ~80% of all MCCs. However, a cohort from Australia found a rate of just 24%, suggesting an alternative mechanism; ultra violet (UV) exposure was suspected and later confirmed using genomic mutational signature analysis. Are these are two separate diseases, requiring different clinical management strategies for best patient outcomes?

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Robb T

Authors: Robb T, Woodhouse B, Parker K, Miller R, Hayward G,

Keywords: merkel, ddPCR, diagnostics, genomics,

#2281 A Novel Classification of Pancreatic Neuroendocrine Tumors (pNETs) Guided by Genomics

Introduction: NET outcomes differ by primary site. Yet pNETs are classified using a generic GI grading system.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Lawrence B

Authors: Lawrence B, Blenkiron C, Parker K, Yeong M, Kramer N,

Keywords: pancreatic NET, genomics,

#2272 Enhancing Diagnostic Precision Through Combined Genomic and Histopathological Analysis of Pancreatic Neuroendocrine Tumors

Introduction: Diagnostic differentiation of uncommon pancreatic malignancies can be challenging, but is essential for accurate clinical management; genomic analysis may provide a tool for making this critical distinction.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Lawrence B

Authors: Robb T, Yeong M, Kramer N, Blenkiron C, Parker K,

Keywords: precision medicine, diagnostics, histology, pathology, histo-pathology, genomics,