A Novel Classification of Pancreatic Neuroendocrine Tumors (pNETs) Guided by Genomics


Introduction: NET outcomes differ by primary site. Yet pNETs are classified using a generic GI grading system.

Aim(s): Genomics may assist prognostication of pNET behaviour in the clinic.

Materials and methods: We report deep genomic analysis of pNETs from 57 patients using a NimbleGen SeqCap comprehensive panel (n=578 genes) augmented with a custom NET–specific panel (n=57 genes) at ~780X coverage) and Affymetrix PrimeView RNA expression arrays (~36,000 transcripts). Bioinformatics were conducted using in-house pipelines customised for NETs.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Lawrence B

Authors: Lawrence B, Blenkiron C, Parker K, Yeong M, Kramer N,

Keywords: pancreatic NET, genomics,

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