Enhancing Diagnostic Precision Through Combined Genomic and Histopathological Analysis of Pancreatic Neuroendocrine Tumors

#2272

Introduction: Diagnostic differentiation of uncommon pancreatic malignancies can be challenging, but is essential for accurate clinical management; genomic analysis may provide a tool for making this critical distinction.

Aim(s): To augment traditional pathology with multi-modal genomic analysis in order to improve diagnostic differentiation of rare pancreatic malignancies.

Materials and methods: Targeted DNA sequencing, RNA expression analysis and immunohistochemistry (IHC) alongside pathological examination were employed to search for molecular drivers in a study of 60 patients with pancreatic neuroendocrine tumours (pNETs), and incidentally provided valuable evidence for re-diagnosis.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Lawrence B

Authors: Robb T, Yeong M, Kramer N, Blenkiron C, Parker K,

Keywords: precision medicine, diagnostics, histology, pathology, histo-pathology, genomics,