Abstract Library

#4604 Germline predisposition to neuroendocrine tumours of the pancreas (pNEN) based on mutations in DNA repair genes – BRCA1, BRCA2, PALB2, CHEK2, MLH1, MSH2, MSH6, PMS2, EPCAM, APC, MUTYH, STK11

Introduction: Neuroendocrine tumours of the pancreas (pNEN) rank as the second most common epithelial neoplasms after pancreatic adenocarcinoma, with increasing prevalence and a mortality rate of 60%. Identifying germline mutations in DNA repair genes such as CHEK2, BRCA1/2, and MUTYH within pNEN cases may pave the way for personalised diagnostics and therapies.

Conference:

Presenting Author:

Authors: Jurecka Lubieniecka B, Ros-Mazurczyuk M, Oczko-Wojciechowska M, Cortez A, Handkiewicz-Junak D,

Keywords: pNEN, DNA repair genes,

#4549 Alpha-Fetoprotein as a valuable biomarker in neuroendocrine tumours

Introduction: Neuroendocrine tumours (NETs) are a rare group of tumours that pose a significant diagnostic, therapeutic, and prognostic challenge. This complexity arises from the diversity and heterogeneity of these neoplasms, as well as from the limitations of commonly used biomarkers in clinical practice. Alpha-fetoprotein (AFP) is a fetal protein widely used primarily for congenital defects in prenatal diagnostics and in certain malignancies in adults.

Conference:

Presenting Author:

Authors: Musiałkiewicz J, Gut P, Komarnicki P, Maciejewski A, Ruchała M,

Keywords: alpha-fetoprotein, biomarker, neuroendocrine tumour,

#4321 Insulinoma – A diagnostic challenge

Introduction: Insulinomas are rare pancreatic neuroendocrine neoplasms (pNEN). Operative resection is the treatment of choice.

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Presenting Author:

Authors: Ritter A, Poppinga J, Steinkraus K, von Kroge P, Amin T,

Keywords: Neuroendocrine neoplasia, insulinoma, pancreatic NEN, hypoglycaemia,

#3462 Development and verification of a new monoclonal OTP specific antibody for pulmonary carcinoid diagnostics

Introduction: Histology-based grading of pulmonary carcinoids (PC) is problematic and subject to high interobserver variation. Orthopedia homeobox (OTP) has shown to be an excellent prognostic marker for PCs, also indicated by the WHO. However, absence of a reliable routinely applicable monoclonal OTP antibody (mAb) hampers implementation in routine diagnostics.

Conference:

Presenting Author: Speel E

Authors: Moonen L, Derks J, Lap L, Marijnissen B, van den Bosch T,

Keywords: Orthopedia Homeobox, pulmonary carcinoid, monoclonal antibody, clinical diagnostics,

#3373 Educational learning investigational observational study (ELIOS): A 10-year Italian network to standardize procedures and obtain multicentric clinical research studies

Introduction: Neuroendocrine neoplasms (NEN) are heterogeneous tumors with peculiar biology and rising incidence. Multidisciplinary approach in skilled centers is required to manage these patients. Accurate and complete data are indispensable for high quality epidemiological and clinical research.

Conference:

Presenting Author:

Authors: Modica R, Tafuto S, Riccardi F, Di Sarno A, Rodriquenz M,

Keywords: neuroendocrine, research, network,