Abstract Library

#3015 Biopsy Specimen Diagnosis in Pulmonary Carcinoids, A Shot in the Dark

Introduction: Pulmonary carcinoids (PCs) are rare well-differentiated neuroendocrine tumors, which can be separated into typical carcinoid (TC) and atypical carcinoid (AC). Advised treatment for local carcinoid disease is surgical resection using lobectomy, while parenchymal saving strategies such as sub-lobar or endobronchial resection might be considered for TC. In general, pre-operative diagnosis using a (transbronchial/transthoracic) biopsy sample is performed to demonstrate malignancy. However, TC and AC classification can solely be performed on surgical resection specimens, which may challenge pre-operative treatment decisions.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Moonen L

Authors: Moonen L, Derks J, Hermans B, Dingemans A, Speel E,

Keywords: pulmonary, neuroendocrine, carcinoid, biopsy, resection, diagnosis,

#1936 The Expression of IGF Signaling Pathway Genes Is Frequently Elevated in Pancreatic Neuroendocrine Tumors, but Is Downregulated in Metastases

Introduction: Studies have implicated EGFR, IGF and mTOR signaling pathways in the regulation of pNET growth. Interpretation of these studies is complex due to tumor subtype heterogeneity and differences in molecular analysis.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Speel E

Authors: Henfling M, Versleijen-Jonkers Y, Starke A, Riedl R, Sprij-Mooij D,

Keywords: , ,

#1192 Clinical Characteristics and Overall Survival of Large Cell Neuroendocrine Carcinoma (LCNEC) Compared to Other Subtypes of Lung Cancer: Results of a Population-based Registry

Introduction: LCNEC is a rare non-small cell lung cancer subtype and clinical behavior is unclear.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Derks J

Authors: Derks J, Hendriks L, Damhuis R, Speel E, Dingemans A,

Keywords: LCNEC, lung,

#69 Frequent biological association of Merkel cell polyomavirus with Merkel cell carcinomas

Introduction: Merkel cell polyomavirus (MCPyV) DNA has been detected by PCR in 75–100% of Merkel cell carcinomas (MCC), an aggressive neuroendocrine skin cancer. MCPyV is a 5.4 kb DNA virus that expresses tumor (T) antigen in tumor tissues.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Speel E

Authors: Speel E, Schmidt A, Baumann M, Haesevoets A, Diebold J,

Keywords: Merkel cell polyoma virus, Merkel cell carcinoma, neuroendocrine skin cancer, FISH, large T antigen,