The Expression of IGF Signaling Pathway Genes Is Frequently Elevated in Pancreatic Neuroendocrine Tumors, but Is Downregulated in Metastases


Introduction: Studies have implicated EGFR, IGF and mTOR signaling pathways in the regulation of pNET growth. Interpretation of these studies is complex due to tumor subtype heterogeneity and differences in molecular analysis.

Aim(s): To examine gene and protein expression of EGFR, IGF and mTOR signaling pathway components in (non)insulinoma pNETs.

Materials and methods: Insulinomas were analysed by qRT-PCR (n=48) and immunohistochemistry (n=88). Protein expression was compared with that of 92 non-insulinomas (12 gastrinomas, 11 glucagonomas, 10 vipomas and 59 non-functioning). Findings were compared with normal pancreatic islands and correlated with histopathological data and outcome.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Speel E

Authors: Henfling M, Versleijen-Jonkers Y, Starke A, Riedl R, Sprij-Mooij D,

Keywords: , ,

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