Clinical Characteristics and Overall Survival of Large Cell Neuroendocrine Carcinoma (LCNEC) Compared to Other Subtypes of Lung Cancer: Results of a Population-based Registry


Introduction: LCNEC is a rare non-small cell lung cancer subtype and clinical behavior is unclear.

Aim(s): To analyze incidence, patient (pt) characteristics, metastatic pattern and overall survival (OS) of LCNEC and compare data with small-cell (SCLC), squamous cell (SqCC) and adenocarcinomas (AdC).

Materials and methods: Histologically confirmed LCNEC, SCLC, SqCC and AdC cases diagnosed between 2003-2012 were selected from the Netherlands Cancer Registry. Cohorts of stage I-II, III and IV disease were compared for pt characteristics, metastasis at diagnosis (≥2006) and OS. Multivariate Cox regression was performed; if non-proportional, time dependent Hazard ratios (HR) were reported.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Derks J

Authors: Derks J, Hendriks L, Damhuis R, Speel E, Dingemans A,

Keywords: LCNEC, lung,

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