Abstract Library

Welcome to the open-access search for all ENETS abstracts presented at the Annual ENETS Conferences.

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ENETS Abstract Search

#3886 Large cell neuroendocrine carcinoma subtyping based on NEUROD1, ASCL1, POU2F3 and YAP1 expression

Introduction: Large cell neuroendocrine carcinoma (LCNEC) accounts for 1-3% of all types of lung cancer and is, similar to small-cell lung cancer (SCLC), a high-grade tumor with poor prognosis. pRb can also be used to subclassify LCNEC into SCLC-like and NSCLC-like. SCLC can be classified in 4 transcriptomic subtypes (NEUROD1high, ASCL1high, POU2F3high, YAP1high), which may have therapeutic implications. It is unclear whether these subtypes are also found in LCNEC and if they correlate with pRb expression.

Conference:

Presenting Author: Heijboer F

Authors: Rijnsburger N, Heijboer F, Derks J, Hermans B, Hillen L,

Keywords: LCNEC, pulmonary, immunohistochemistry, pathology, pRb, transcription factors,

#3867 Radiological follow-up (FU) in resected pulmonary typical carcinoids (pTC) – Do the benefits outweigh the risks?

Introduction: Primary resection is treatment of choice of pulmonary carcinoids (PC) and recurrences occur ~7% of TC and ~35% of atypical carcinoid (AC). Because of a risk of late recurrence, even in TC, long-term radiological FU is generally advised. As PC are frequent in relatively young pts, there is a risk of late radiation-induced cancer.

Conference:

Presenting Author: Heijboer F

Authors: Heijboer F, Mulders T, van Straten M, Moonen L, Speel E,

Keywords: pulmonary carcinoid, typical carcinoid, atypical carcinoid, primary resection, follow-up, ct scan,