Abstract Library

#4177 Performance of a prognostic OTP, CD44, Ki-67 biomarker panel on paired biopsies and resections of lung carcinoids

Introduction: Previously OTP, CD44 and ki-67 have been identified as prognostic biomarkers for lung carcinoid (LC).

Conference:

Presenting Author: van Weert T

Authors: van Weert T, Moonen L, Hillen L, von der Thüsen J, Lap L,

Keywords: OTP, CD44, Ki-67, lung carcinoid, relapse prediction,

#4175 Immunohistochemical profiling of lung carcinoid subtypes and marker comparison of matched primary and metastatic tumors

Introduction: Multi-omic studies have identified three lung carcinoid (LC) subtypes (A1, A2, B) with unique gene expression for OTP, ASCL1 & HNF1a.

Conference:

Presenting Author: Leunissen D

Authors: Leunissen D, Moonen L, von der Thüsen J, den Bakker M, Hillen L,

Keywords: lung carcinoid, TTF1, S100, metastatic disease,

#3889 Patterns of recurrence in patients with resected pulmonary carcinoid – A Dutch nationwide study

Introduction: In patients (pts) with resected pulmonary carcinoids (PC), recurrence of disease may occur up to 10 years after surgery, but the exact incidence remains unknown.

Conference:

Presenting Author: Moonen L

Authors: Moonen L, Derks J, Hillen L, den Bakker M, von der Thüsen J,

Keywords: Pulmonary carcinoid, recurrence, surgery, screening, nationwide registry,

#3886 Large cell neuroendocrine carcinoma subtyping based on NEUROD1, ASCL1, POU2F3 and YAP1 expression

Introduction: Large cell neuroendocrine carcinoma (LCNEC) accounts for 1-3% of all types of lung cancer and is, similar to small-cell lung cancer (SCLC), a high-grade tumor with poor prognosis. pRb can also be used to subclassify LCNEC into SCLC-like and NSCLC-like. SCLC can be classified in 4 transcriptomic subtypes (NEUROD1high, ASCL1high, POU2F3high, YAP1high), which may have therapeutic implications. It is unclear whether these subtypes are also found in LCNEC and if they correlate with pRb expression.

Conference:

Presenting Author: Heijboer F

Authors: Rijnsburger N, Heijboer F, Derks J, Hermans B, Hillen L,

Keywords: LCNEC, pulmonary, immunohistochemistry, pathology, pRb, transcription factors,

#3858 OTP, CD44, and Ki-67 – A prognostic marker panel for relapse free survival in patients with surgically resected pulmonary carcinoid

Introduction: Relapse occurs in 10% of patients with resected pulmonary carcinoid (PC). While typical carcinoids (TC) show low relapse rates, safe exclusion from long-term follow-up (FU) is impossible partly due to high interobserver variation in the WHO classification.

Conference:

Presenting Author: Moonen L

Authors: Moonen L, Derks J, den Bakker M, Hillen L, von der Thüsen J,

Keywords: Pulmonary Carcinoid, OTP, CD44, Ki-67, biomarker, prognosis,