Abstract Library

#4187 Psychiatric and cognitive function in patients with serotonin producing neuroendocrine tumors

Introduction: Cognitive and psychiatric problems are common in cancer patients, but literature in patients with neuroendocrine tumors (NET) is scarce. Peripheral serotonin overproduction by the tumor, clinically manifesting as carcinoid syndrome, is hypothesized to be related to cognitive and psychiatric problems, through depletion of serotonin’s precursor tryptophan.

Conference:

Presenting Author: Tesselaar M

Authors: Luijendijk M, Tesselaar M, van Rossum H, Korse C, Verbeek W,

Keywords: Neuroendocrine neoplasm, carcinoid syndrome, cognitive functioning, depression, anxiety, serotonin, tryptophan, 5-HIAA,

#4177 Performance of a prognostic OTP, CD44, Ki-67 biomarker panel on paired biopsies and resections of lung carcinoids

Introduction: Previously OTP, CD44 and ki-67 have been identified as prognostic biomarkers for lung carcinoid (LC).

Conference:

Presenting Author: van Weert T

Authors: van Weert T, Moonen L, Hillen L, von der Thüsen J, Lap L,

Keywords: OTP, CD44, Ki-67, lung carcinoid, relapse prediction,

#4175 Immunohistochemical profiling of lung carcinoid subtypes and marker comparison of matched primary and metastatic tumors

Introduction: Multi-omic studies have identified three lung carcinoid (LC) subtypes (A1, A2, B) with unique gene expression for OTP, ASCL1 & HNF1a.

Conference:

Presenting Author: Leunissen D

Authors: Leunissen D, Moonen L, von der Thüsen J, den Bakker M, Hillen L,

Keywords: lung carcinoid, TTF1, S100, metastatic disease,

#4027 Prognostic impact of molecular signatures in pancreatic metastatic neuroendocrine tumors (PRODETEN)

Introduction: Pancreatic neuroendocrine neoplasms (PNENs) are an heterogenous group of tumors. This heterogeneity is not explained by the main known prognostic factors (extension, evolution slope and Ki67 index). New molecular biomarkers (ARX, ATRX, DAXX, menin, PDX1) seem promising in non-metastatic PNENs.

Conference:

Presenting Author: de Mestier L

Authors: Pokossy Epee J, Cros J, Cadiot G, Do Cao C, Hautefeuille V,

Keywords: pancreas, neuroendocrine, prognostic, ATRX, daxx, arx, pdx1, Super Learner, menin, biomarker,

#3893 Pancreatic neuroendocrine tumor associated hypophosphatemia due to tumor-induced osteomalacia – A case report

Introduction: Tumor-induced osteomalacia (TIO) is a rare syndrome characterised by hypophosphataemia and osteomalacia with renal phosphate wasting caused by elevated levels of fibroblast growth factor 23 (FGF23) in the setting of tumor. The primary tumor is typically found in bone or soft tissue.

Conference:

Presenting Author:

Authors: Storan D, Almeamar H, O'Shea D, O'Toole D, Crowley R,

Keywords: pNET, pancreas, hypophosphataemia, osteomalacia, fgf23,