Pancreatic neuroendocrine tumor associated hypophosphatemia due to tumor-induced osteomalacia – A case report

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Introduction: Tumor-induced osteomalacia (TIO) is a rare syndrome characterised by hypophosphataemia and osteomalacia with renal phosphate wasting caused by elevated levels of fibroblast growth factor 23 (FGF23) in the setting of tumor. The primary tumor is typically found in bone or soft tissue.

Aim(s): We report a rare case of pancreatic neuroendocrine tumor (pNET) associated TIO with elevated levels of FGF23.

Materials and methods: A 74-year-old man was referred for further investigation of hypophosphataemia. He complained of occasional muscle cramps but was otherwise asymptomatic. His background was significant for rheumatoid arthritis, hypertension and radical prostatectomy 8 years ago.

Conference:

Presenting Author:

Authors: Storan D, Almeamar H, O'Shea D, O'Toole D, Crowley R,

Keywords: pNET, pancreas, hypophosphataemia, osteomalacia, fgf23,