Abstract Library

#2930 Treatment of the Pinealoma: Experience from a Rare Case

Introduction: Pinealoma is an extremely rare type of neuroendocrine tumor without evidence-based systemic therapy.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Zhang Y, Liu M, Chen L, Guo Y, Chen M,

Keywords: pinealoma, octreotide, interferon.,

#2176 New MENIN Mutation Associated with Familial Isolated Hyperparathyroidism. Clinical Case of Three Young Sisters.

Introduction: The primary hyperparathyroidism (PHPT) is a sporadic disorder in the majority of cases, and only 5-10% of cases are associated with familial syndromes. The following familial syndromes associated with PHPT are known to date: multiple endocrine neoplasia type 1 (MEN1), type 2A (MEN2A), type 4 (MEN4), hyperparathyroidism-jaw tumor syndrome (HPT-JT), familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT) and familial isolated hyperparathyroidism (FIHP). FIHP is defined as hereditary PHPT without the association with other diseases or tumors and may be caused by mutations in MEN1, HRPT2, or CASR genes.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Krupinova K

Authors: Mokrysheva N, Krupinova J, Eremkina A, Tiulpakov A,

Keywords: primary hyperparathyroidism, familial isolated hyperparathyroidism, familial syndromes, MEN1, parathyroid hyperplasia,

#2165 A Pilot Study of the Cyclin Dependent Kinases 4, 6 Inhibitor Ribociclib in Patients with Foregut Neuroendocrine Tumors

Introduction: Increased cyclin dependent kinases 4, 6 (cdk 4/6) activity is noted in the majority of well differentiated foregut neuroendocrine tumors (fNETs) due to mutations in MENIN and other aberrations. These tumors also have preserved Rb function making cdk 4/6 inhibitors attractive agents for therapy.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Dasari A

Authors: Dasari A, Halperin D, Coya T, Mahvash A, Zorrilla I,

Keywords: Foregut NETs, ribociclib, cdk 4/6,

#2076 Pancreatic Neuroendocrine Tumor in Polish Population with MEN 1 Syndrome

Introduction: The multiple endocrine neoplasia type 1 (MEN 1) is a genetically conditioned syndrome which is characterised by usually mild parathyroid and pituary gland adenomas, pancreatic neuroendocrine tumor (pNET). The last appear in 30-70% of MEN 1 patients being main life-threatening manifstation among MEN 1 patients. The prognosis might improve by presymptomatic tumor detection.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Soczomski P, Jurecka-Lubieniecka B, Rogozik N, Grajewska-Ferens M, Michalik B,

Keywords: Multiple endocrine neoplasia, Menin, Pancreatic Neuroendocrine Tumor, Polish population,

#1722 New MEN-1 Gene Mutation Implicated in Familiar MEN-1 Syndrome Onset

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare genetic syndrome associated with an increased risk of developing parathyroid, pituitary and pancreatic neuroendocrine tumors. MEN1 has an autosomal dominant pattern of hereditability and it is usually related to mutations in menin coding gene

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Grego E, Pellicciari M, Novak L, Ortolani S, Antista M,

Keywords: MEN1 syndrome, MEN1 gene mutation, neuroendocrine tumor,