ATRX, DAXX, and menin immunohistochemistry identify prognostic relevant non-functioning neuroendocrine tumours subgroups

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Introduction: Non-functioning pancreatic neuroendocrine tumours (NF-pNETs) are rare tumours with a variable prognosis. Recent studies have identified prognostic subgroups based on ATRX, DAXX and MEN1 mutations along with chromosomal aneuploidies.

Aim(s): This study aims to classify prognostic groups using immunohistochemical expression of proteins ATRX, DAXX, and Menin, representing the ATRX, DAXX, and MEN1 genes.

Materials and methods: Primary sporadic grade 1 and grade 2 NF-pNETs without synchronous metastases were retrospectively retrieved from local pathology archives and analysed using tissue microarrays. Immunohistochemical staining for ATRX, DAXX, and Menin was performed, and pNETs were classified into three groups: Group pNET1 (ATRX/DAXX loss), group pNET2 (Menin loss without ATRX/DAXX loss), and group pNET3 (no ATRX/DAXX or Menin loss). Survival analysis was conducted to evaluate the prognostic significance of these subgroups.

Conference:

Presenting Author: Verschuur A

Authors: Verschuur A, Jairam J, Eldem B, Singhi A, Hackeng W,

Keywords: pancreatic neuroendocrine tumour, ATRX, DAXX, MEN1, menin, biomarker,