Diagnostic utility of menin immunohistochemistry in MEN1 syndrome patients

#3896

Introduction: A clinical diagnosis of Multiple Neoplasia type 1 (MEN1) syndrome is confirmed with genetic testing. It is expected that menin protein expression is lost in MEN1 related tumors.

Aim(s): Therefore, we investigated the potential of menin immunohistochemistry in parathyroid adenomas as an additional tool in the recognition and genetic diagnosis of MEN1 syndrome.

Materials and methods: Local pathology archives were searched for parathyroid adenomas from patients with MEN1 syndrome and without MEN1, including sporadic, multiple endocrine neoplasia type 2A and hyperparathyroidism-jaw parathyroid tumor patients. Menin immunohistochemistry was performed and its use to identify MEN1 related tumors was assessed.

Conference:

Presenting Author: Verschuur A

Authors: Verschuur A, Kok A, Morsink F, de Leng W, van den Broek M,

Keywords: MEN1, MEN1 syndrome, parathyroid, parathyroid adenoma, menin, immunohistochemistry,