Abstract Library

#2902 DNA Methylation Analysis of the PDX1 Gene Can Be Used for PNET Subtyping and Has a Possible Prognostic Value

Introduction: Estimating prognosis of pancreatic neuroendocrine tumor (PNET) patients remains challenging. Mutation status of DAXX/ATRX/MEN1, histone modification patterns and immunohistochemistry for relevant transcription factors, including PDX1, were recently used to perform subtyping and distinguished two main types, A and B. These subtypes are linked to cell-of-origin and associated with clinical outcome.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Boons G, Vandamme T, Ibrahim J, Schepers A, Roeyen G,

Keywords: Pancreatic Neuroendocrine Tumor, DNA Methylation, Prognostic Biomarker,

#171 Transcription Factor Signature in Pancreatic and Duodenal Neuroendocrine Neoplasms

Introduction: We recently identified ISL1 as a marker for pancreatic neuroendocrine neoplasms (P-NENs). ISL1 as well as PDX1, CDX2 and NGN3 are transcription factors (TF) involved in pancreato-duodenal development.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Hermann G, Klöppel G, Konukiewitz B, Schmitt A, Perren A,

Keywords: neuroendocrine, neoplasm, pancreas, duodenum, transcription factors, isl1, pdx1, ngn3, cdx2, ihc,