Abstract Library
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ENETS Abstract Search
Introduction: Estimating prognosis of pancreatic neuroendocrine tumor (PNET) patients remains challenging. Mutation status of DAXX/ATRX/MEN1, histone modification patterns and immunohistochemistry for relevant transcription factors, including PDX1, were recently used to perform subtyping and distinguished two main types, A and B. These subtypes are linked to cell-of-origin and associated with clinical outcome.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Boons G, Vandamme T, Ibrahim J, Schepers A, Roeyen G,
Keywords: Pancreatic Neuroendocrine Tumor, DNA Methylation, Prognostic Biomarker,
Introduction: Recent studies in pancreatic neuroendocrine tumors have identified mutations in DAXX/ATRX, MEN1, and genes involved in the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin (PI3K-Akt-mTOR) pathway. However, these studies focused on abundant mutations.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Vandamme T
Authors: Vandamme T, Beyens M, Van Camp G, Boons G, Hofland L,
Keywords: pancreatic neuroendocrine tumors, PNET, genetics, tumor heterogeneity, hotspot mutations,
#2139 Genome-Wide DNA Methylation Profiling of Pancreatic Neuroendocrine Tumors
Introduction: Frequent inactivation of epigenetic regulators ATRX and DAXX in pancreatic neuroendocrine tumors (PNETs) suggests an important role for epigenetic alterations in tumorigenesis. Few studies have been published regarding differential methylation patterns in PNETs and a thorough analysis of these alterations is currently lacking.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author:
Authors: Boons G, Beyens M, Schepers A, Vandamme T, Roeyen G,
Keywords: pancreatic neuroendocrine tumor, DNA methylation,