Abstract Library
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ENETS Abstract Search
Introduction: Immunohistochemical expression of synaptophysin (SYN), chromogranin (CgA) and cytokeratin are essential for diagnosis of NENs. Non-NENs, however, may occasionally also express NE-markers and cytokeratin and cause diagnostic difficulties.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Kasajim A
Authors: Kasajima A, Konukiewitz B, Schlitter A, Weichert W, Klöppel G,
Keywords: pitfalls, pathology diagnosis,
Introduction: G3 gastroenteropancreatic neuroendocrine tumors (G3 NET) and carcinomas (G3 NEC) differ considerably concerning their biological behavior and patients outcome. Whereas the WHO2017 classification for pancreatic NETs proposes a distinction of both groups using the Ki-67 proliferation marker (Klöppel et al. Reviews and Reports 2017), a useful marker for the subclassification of G3 intestinal NETs have not been recommended until now.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Briest F
Authors: Briest F, Konukiewitz B, Anlauf M, Klöppel G, Grabowski P,
Keywords: gastroenteropancreatic neuroendocrine tumors, GEP-NET, NET G3, NEC G3, Tumor marker, FOXM1, Ki-67, differentiation,
Introduction: Prognostic impact of well differentiated pancreatic neuroendocrine neoplasms (PanNENs) with a Ki67 >20%, provisionally called NET G3, needs to be validated and compared to poorly differentiated neuroendocrine carcinomas (NECs). Moreover, the frequency of NET G3 among gastrointestinal NENs (GI-NENs) has so far not been studied.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Kasajima A
Authors: Kasajima A, Tachibana T, Ishida H, Yazdani S, Konukiewitz B,
#558 MANECs Among Colorectal Signet Ring Cell Carcinomas
Introduction: The mixed adenoneuroendocrine carcinomas (MANEC, WHO 2010) are neoplasms with heterogeneous morphology, whose mixed nature may be difficult to recognize.
Conference: 9th Annual ENETSConcerence (2012)
Presenting Author:
Authors: Hermann G, Yarom N, Konukiewitz B, Sandbank J, Klöppel G,
Keywords: manec, signet ring cell carcinoma, colon, rectum,
#171 Transcription Factor Signature in Pancreatic and Duodenal Neuroendocrine Neoplasms
Introduction: We recently identified ISL1 as a marker for pancreatic neuroendocrine neoplasms (P-NENs). ISL1 as well as PDX1, CDX2 and NGN3 are transcription factors (TF) involved in pancreato-duodenal development.
Conference: 8th Annual ENETSConcerence (2011)
Presenting Author:
Authors: Hermann G, Klöppel G, Konukiewitz B, Schmitt A, Perren A,
Keywords: neuroendocrine, neoplasm, pancreas, duodenum, transcription factors, isl1, pdx1, ngn3, cdx2, ihc,