The dominant role of pancreatic and pulmonary NET G3 in a large consultation center series

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Introduction: NETs G3 have been reported mostly in the pancreas, but other primary sites have not been well-investigated. Pulmonary atypical carcinoids corresponding to NET G3 were observed as metastases. Little is known about the progression of primary NETs to metastatic NET G3.

Aim(s): To clarify, first, where and how often NET G3 occurs de-novo (“primary” NET G3), second, how many NETs G3 are identified as metastases, and third, how often NET G3 evolves from NET G1/G2 (“secondary” NET G3).

Materials and methods: 1513 NENs retrieved to our consultation center were classified based on the WHO classification of digestive system tumors.

Conference:

Presenting Author: Kasajima A

Authors: Kasajima A, Konukiewitz B, Schlitter A, Weichert W, Klöppel G,

Keywords: Neuroendocrine Tumor G3, Prevalence, Origin, Metastasis, Development,