Hormonally characterised NF-PanNETs and their clinicopathological features

#4172

Introduction: PanNETs show pronounced hormonal heterogeneity. The expression of certain hormones may associate with functional syndromes, but also with histological and genetic features. However, detailed studies of hormonal patterns in PanNETs correlated to morphological and clinical data are lacking.

Aim(s): To identify hormonal patterns in PanNETs that associate with histological and clinical findings.

Materials and methods: Expression of orthotopic hormones (insulin, glucagon, PP, somatostatin, serotonin) and ectopic hormones (ACTH, gastrin, calcitonin) was immunohistochemically studied in 153 surgically resected non-functioning (NF, N=137) and functioning (F, N=16)-PanNETs. The results were correlated with histological features, expression of transcriptional factors (ARX, PDX1, ISL1, CDX2) and clinical outcome.

Conference:

Presenting Author: Moser E

Authors: Moser E, Ito A, Vogel L, Steiger K, Scheidhauer K,

Keywords: Neuroendocrine Tumor, hormonal expression, subtypes, outcome, transcriptional factors,