Abstract Library
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#3320 TGF-β increase caspase activation and migration in typical bronchial carcinoids
Introduction: Typical bronchial carcinoids (TBC) are well-differentiated neuroendocrine neoplasms (NEN) whose management can still be very challenging due to reduced sensitivity to therapy. Previous studies have reported TGF-β’s ability to activate mTOR pathway and induce epithelial to mesenchymal transition (EMT). Moreover, preliminary results show an overexpression of TGF-β signalling and caspase activation in TBC.
Conference: 18th Annual ENETS Concerence (2021)
Presenting Author: Gagliardi I
Authors: Borges de Souza P, Gagliardi I, Martelli M, Zatelli M,
Keywords: bronchial carcinoid, TGF-β signalling, mTOR, EMT,
Introduction: Rb and p53 status may help distinguishing well from poorly differentiated neuroendocrine neoplasms (NEN) and may predict response to chemotherapy. Studies correlating Rb/p53 genetic and immunohistochemistry were performed on high-quality frozen samples with high throughput techniques efficient for copy number determination. This situation differs from routine practice in which small deletions may be hard to detect on formalin-fixed paraffin-embedded (FFPE) samples with a gene panel approach.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Cros J
Authors: Chen R, Lacroix L, De Rycke O, Lacombe C, Cazes A,
Keywords: rb, p53, aggressive neuroendocrine tumors, biomarker,
Introduction: Gastroenteropancreatic neuroendocrine tumours (GEP NET) can adversely affect nutritional status. Cross-sectional studies report up to 25% of GEP NET patients are malnourished and dietary change may be prevalent. Nevertheless, clinical guidelines lack advice on nutrition management.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Laing E
Authors: Laing E, Kiss N, Michael M, Krishnasamy M, Gough K,
Keywords: neuroendocrine, nutrition, malnutrition, weight change, symptoms,
Introduction: Neuroendocrine liver metastases are clinically challenging and often non-resectable due to their frequent disseminated distribution. Radioembolisation with yttrium-90 labelled microspheres represents an emerging modality for NELM.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Clift A
Authors: Clift A, Frilling A, Braat A, Alsafi A, Wasan H,
Keywords: liver, metastases, radioembolization, yttrium, selective internal radiation therapy,
Introduction: The antiproliferative effect of first-line long acting somatostatin analogs (SSA) in advanced gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) was shown in the PROMID and the CLARINET trials. Efficacy data in pancreatic NETs (PanNETs) with Ki-67 ≥ 10% are limited.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Merola E
Authors: Merola E, Alonso Gordoa T, Zhang P, Al-Toubah T, Pelle E,
Keywords: Pancreatic NET, Somatostatin Analogs, Grade 2 and 3, Safety, Efficacy,