Abstract Library

#2297 Merkel Cell Carcinomas in New Zealand: Virus or Ultra Violet?

Introduction: Merkel Cell Carcinoma (MCC) is a rare Neuroendocrine skin tumour. MCC behavior is more aggressive than the more common Melanoma, with treatments often restricted to surgery or radiotherapy, although immunotherapy holds promise overseas. In 2008, a USA study identified an oncogenic polyomavirus (MCPyV) present in eight of ten tested MCC tumours. Studies from across Europe and the USA confirmed MCPyV presence in ~80% of all MCCs. However, a cohort from Australia found a rate of just 24%, suggesting an alternative mechanism; ultra violet (UV) exposure was suspected and later confirmed using genomic mutational signature analysis. Are these are two separate diseases, requiring different clinical management strategies for best patient outcomes?

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Robb T

Authors: Robb T, Woodhouse B, Parker K, Miller R, Hayward G,

Keywords: merkel, ddPCR, diagnostics, genomics,

#1815 MicroRNAs Associated with Small Bowel Neuroendocrine Tumours and Their Metastases

Introduction: Novel molecular analytes are needed in small bowel NETs (SBNETs) to better determine disease aggressiveness and predict treatment response.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Frampton A

Authors: Frampton A, Miller H, Malczewska A, Ottaviani S, Stronach E,

Keywords: miRNA, small bowel neuroendocrine tumour,

#1372 The Role of Interval CT Scanning in Patients Undergoing Palliative Chemotherapy for Metastatic Neuroendocrine Tumours (NETs)

Introduction: In NET, radiological response to chemotherapy is often delayed and the importance of interval-imaging during treatment has not been determined.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Miller R, Childs A, Gillmore R, Mayer A, Thirlwell C,

Keywords: NETs, chemotherapy, imaging,

#961 Heterogeneity in the Ki-67 Index of Neuroendocrine Tumors

Introduction: Tumor heterogeneity due to tumor evolution is becoming more widely recognised. Neuroendocrine tumors (NET) are routinely graded using the Ki-67 index based on a single tumor location, however, this could lead to undergrading if the Ki-67 index is higher at the metastatic site.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Miller H, Flora R, Drymousis P, Wasan H, Goldin R,

Keywords: tumor heterogeneity, Ki-67,

#691 Pancreatic Focal Alpha Cell Hyperplasia with Hyperglucagonaemia without the Glucagonoma Syndrome

Introduction: Pancreatic alpha cell hyperplasia and hyperglucagonaemia without the glucagonoma syndrome is a rare clinical syndrome not widely recognised. Here we describe a novel mutation in the glucagon receptor gene (GCGR) in a patient with the disease.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Miller H, Baird D, Kidd M, Cohen P, Vlavianos P,

Keywords: glucagon receptor, mutation,