MicroRNAs Associated with Small Bowel Neuroendocrine Tumours and Their Metastases

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Introduction: Novel molecular analytes are needed in small bowel NETs (SBNETs) to better determine disease aggressiveness and predict treatment response.

Aim(s): To profile the global miRNome of SBNETs and identify miRNAs involved in tumour progression for use as potential biomarkers.

Materials and methods: Two independent miRNA profiling experiments were performed(n=90), including primary SBNETs(n=28), adjacent normal small bowel(NSB;n=14), matched lymph node(LN) metastases(n=24), normal LNs (n=7), normal liver(n=2) and liver metastases(n=15). We then evaluated potentially targeted genes by performing integrated computational analyses.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Frampton A

Authors: Frampton A, Miller H, Malczewska A, Ottaviani S, Stronach E,

Keywords: miRNA, small bowel neuroendocrine tumour,