Abstract Library

#3967 10 years' experience of managing small intestinal neuroendocrine tumors at an ENETS Centre of Excellence

Introduction: Small intestinal NET (SINET) are often diagnosed at advanced stages and may require multiple lines of therapy (multimodal) to attain disease control.

Conference:

Presenting Author:

Authors: Clift A, Drymousis P, von Roon A, Humphries A, Goldin R,

Keywords: small bowel, surgery, multimodal,

#1718 Enhanced Prognostication of Grade 1 Small Bowel Neuroendocrine Tumours with Multi-Parametric Clinicopathological Assessment

Introduction: Most small bowel neuroendocrine tumours (SBNET) are Grade 1 (G1), and exhibit at least nodal metastasis at diagnosis. The clinical behaviours of G1 SBNET remain poorly predictable. The ‘NET nomogram’ developed by Modlin et al. designates SBNET as low/medium/high risk by mathematical analysis of 15 clinicopathological parameters.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Clift A

Authors: Clift A, Faiz O, Goldin R, Martin J, Wasan H,

Keywords: nomogram, stage, grade,

#961 Heterogeneity in the Ki-67 Index of Neuroendocrine Tumors

Introduction: Tumor heterogeneity due to tumor evolution is becoming more widely recognised. Neuroendocrine tumors (NET) are routinely graded using the Ki-67 index based on a single tumor location, however, this could lead to undergrading if the Ki-67 index is higher at the metastatic site.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Miller H, Flora R, Drymousis P, Wasan H, Goldin R,

Keywords: tumor heterogeneity, Ki-67,

#682 Neuroendocrine Tumors, Searching for New Prognostic Biomarkers

Introduction: Neuroendocrine tumors (NET) of the digestive system were once considered relatively rare, however, the incidence is increasing. New prognostic biomarkers are needed for assessment of tumor behavior to inform patient treatment and improve outcome. The proliferation marker, Ki-67, is used for NET grading. Although classified as low grade, some tumors actually develop metastases.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Miller H, Flora R, Drymousis P, Goldin R, Frilling A,

Keywords: neuroendocrine, apoptosis, markers,