Abstract Library

#3981 Identifying patients with undiagnosed small intestinal neuroendocrine tumors using statistical and machine learning: Model development and validation study

Introduction: Diagnosis of small intestinal neuroendocrine tumors (SI-NETs) is often delayed due to non-specific symptoms and lack of awareness among primary and secondary care physicians. Earlier diagnosis may lead to improved clinical and patient outcomes. Clinical prediction models using machine learning could present novel opportunities for expedited diagnosis in primary care.

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Presenting Author:

Authors: Clift A, Mahon H, Khan G, Boardman-Pretty F, Worker A,

Keywords: machine learning, artificial intelligence, diagnosis, neuroendocrine tumor,

#3968 A systematic review of hepatic transplantation for neuroendocrine liver metastases – Focus on long-term outcomes

Introduction: Neuroendocrine neoplasms frequently metastasise to the liver. Neuroendocrine liver metastases (NELM) may be treated with a broad range of therapeutic options - liver transplantation (LT) being an uncommon, potentially promising, but controversially debated approach.

Conference:

Presenting Author: Clift A

Authors: Palaniappan V, Lei C, Frilling A, Clift A,

Keywords: liver metastases, transplantation, systematic review,

#3967 10 years' experience of managing small intestinal neuroendocrine tumors at an ENETS Centre of Excellence

Introduction: Small intestinal NET (SINET) are often diagnosed at advanced stages and may require multiple lines of therapy (multimodal) to attain disease control.

Conference:

Presenting Author:

Authors: Clift A, Drymousis P, von Roon A, Humphries A, Goldin R,

Keywords: small bowel, surgery, multimodal,

#3058 Diagnosis and Assessment of Effectiveness of Surgical Resection of Small Bowel Neuroendocrine Tumours: The Roles of Circulating MicroRNAs

Introduction: MicroRNAs (miRNA) are small noncoding RNA molecules implicated in the pathophysiology of myriad neoplasms. Clinically useful biomarkers are needed in SB NET to ascertain disease aggressiveness, select treatment strategy, detect early recurrence and monitor response.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Clift A

Authors: Malczewska A, Frampton A, Prado M, Ameri S, Dabrowska A,

Keywords: neuroendocrine, small bowel, intestine, microRNA, biomarker,

#3050 Radioembolization for Neuroendocrine Liver Metastases: An Institutional Case Series, Systematic Review and Meta-Analysis

Introduction: Neuroendocrine liver metastases are clinically challenging and often non-resectable due to their frequent disseminated distribution. Radioembolisation with yttrium-90 labelled microspheres represents an emerging modality for NELM.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Clift A

Authors: Clift A, Frilling A, Braat A, Alsafi A, Wasan H,

Keywords: liver, metastases, radioembolization, yttrium, selective internal radiation therapy,