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Diagnosis and Assessment of Effectiveness of Surgical Resection of Small Bowel Neuroendocrine Tumours: The Roles of Circulating MicroRNAs


Introduction: MicroRNAs (miRNA) are small noncoding RNA molecules implicated in the pathophysiology of myriad neoplasms. Clinically useful biomarkers are needed in SB NET to ascertain disease aggressiveness, select treatment strategy, detect early recurrence and monitor response.

Aim(s): To discover serum-based miRNA biomarkers for small-bowel neuroendocrine tumours (SBNET) to help guide clinical decisions.

Materials and methods: There were 3 phases: discovery; validation; and prospective, longitudinal assessment. Discovery constituted profiling of 376 miRNA in sera from SBNET patients (n = 11) vs. healthy controls (n = 3). Up-regulated miRNAs were subsequently validated in additional SBNET (n = 33) and control sera (n = 14); and then longitudinally after SBNET resection (n = 12), with serial serum sampling (preoperatively day 0; postoperatively at 1 week, 1 month, and 12 months).

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Clift A

Authors: Malczewska A, Frampton A, Prado M, Ameri S, Dabrowska A,

Keywords: neuroendocrine, small bowel, intestine, microRNA, biomarker,

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