Abstract Library

#1227 Molecular Profiling of Small Intestinal Neuroendocrine Tumours (SINETs)

Introduction: Aberrant DNA methylation plays an role in the pathogenesis of many cancers, however little is known about its role in SINET development.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Thirlwell C

Authors: Karpathakis A, Feber A, Morris T, Dibra H, Pipinikas C,

Keywords: Epigenetics, methylation, GIPR, biomarker,

#969 Identification of Hypoxia Induced Epigenetic Changes in the Development of Pancreatic Neuroendocrine Tumors

Introduction: In VHL syndrome, pancreatic NETs develop through bi-allelic inactivation of VHL with subsequent HIF pathway activation. This also occurs in sporadic pancreatic NETs.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Dibra H, Connor T, Ashcroft M, Maxwell P, Thirlwell C,

Keywords: neuroendocrine, von Hippel-Lindau (VHL), hypoxia, epigenetics,

#936 Promoter Hypermethylation at RASSF1 is a Feature of Small Intestinal Neuroendocrine Tumors

Introduction: Promoter hypermethylation of RASSF1 has been reported in many tumor types.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Karpathakis A

Authors: Karpathakis A, Dibra H, Morris T, Feber A, Mandair D,

Keywords: Epigenetics, methylation, RASSF1,

#440 The First Neuroendocrine Tumor Methylome Using Methylation-Specific Immunoprecipitation Followed by Second Generation Sequencing – MeDIP-seq

Introduction: Recently, the first cancer methylomes have been created which identified differential methylation at CpG island-shores (2kb upstream of CpG islands) to be of particular importance in the tumourigenic process.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Thirlwell C, Sasmaz S, Dibra H, Feber A, Butcher L,

Keywords: DNA methylation, neuroendocrine ,