Epigenetic prediction of aging and metabolic traits provides insight into tumor biology in multi-focal ileal neuroendocrine tumors

#4256

Introduction: Approximately half of small intestinal neuroendocrine tumors (siNETs) are multifocal, and recent investigations into the genetic architecture of these tumors have found that they are not clonal. Due to the low mutational rate and slow growing nature of these small tumors, the ‘timing’ of the development of individual tumors has not been possible.

Aim(s): To assess the epigenetic age and predicted metabolic traits of multifocal siNETs.

Materials and methods: Using genome-wide DNA methylation data, we assessed the epigenetic age profiles of 100 samples from 11 patients and compared these with matched whole genome sequencing (WGS) data. We applied the epigenetic clock and several other epigenetic predictors to the dataset, then compared these outcomes with matched WGS data.

Conference:

Presenting Author:

Authors: Webster A, Makinen N, Ecker S, Beck S, Nakakura E,

Keywords: DNA methylation, Epigenetics, Multifocal Ileal Neuroendocrine Tumor, Multifocal Small Instestinal NET, Metabolic Traits,