Abstract Library

#3857 The use of quantitative contrast-enhanced endoscopic ultrasound in the evaluation of pancreatic neuroendocrine tumors – Can we move from quality to quantity? A proof-of-concept study

Introduction: Contrast-enhanced EUS (CE-EUS) is a helpful tool for the diagnosis of pancreatic focal lesions, as pancreatic cancer (PC) and pancreatic neuroendocrine tumor (pNEN). The enhancement of the lesion after contrast medium injection is usually assessed qualitatively and arbitrarily by the endosonographer. Dedicated software has recently been developed to obtain an unbiased quantitative assessment using perfusion parameters.

Conference:

Presenting Author: Tacelli M

Authors: Tacelli M, Bina N, Capurso G, Zaccari P, Petrone M,

Keywords: CE-EUS, pNEN, artificial intelligence, pancreatic cancer, prediction,

#3581 Pancreatic neuroendocrine tumors (PanNETs) vascularization: From “micro” to “macro”

Introduction: Density of microvessels in pancreatic neuroendocrine tumors (PanNETs) changes according to their biological behaviour. Differently from other non-neuroendocrine cancers, a low microvessel density (L-MVD) is associated with higher disease aggressiveness and poorer prognosis.

Conference:

Presenting Author:

Authors: Battistella A, Andreasi V, Palumbo D, Tacelli M, de Cobelli F,

Keywords: pancreatic neuroendocrine tumor, microvessel density, imaging, computed tomography, endoscopic ultrasound, vascularization, enhancement, washout,

#3324 Elastographic localization of insulinoma

Introduction: A 15-year-old healthy female, initially admitted with less serious signs of hypoglycemia. Laboratory studies showed a glucose concentration of 1.2 mmol/l and insulin 9.6 μU/ml. Complete blood count, basal metabolic profile, activity of C - reactive protein and urine drug screen, were unremarkable. Fasting test confirmed biochemical signs of insulinoma.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Uhrík P

Authors: Uhrík P, Nosakova L, Pindura M, Bánovčin P, Hyrdel R,

Keywords: insulinoma, endosonography, elastography,

#2184 4D Ultrasound High Definition Flow with Spatio-Temporal Image Correlation in Evaluation of Neuroendocrine Liver Metastases – Preliminary Study

Introduction: 4D Ultrasound technology merging Power Doppler option called High Definition Flow (HDF) with Spatio-Temporal Image Correlation (STIC) is used in gynecology and obstetrics. It seems to be a promising tool in assessing tissue vascularization.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Janas K, Kudła M, Janas A, Blicharz-Dorniak J, Kos-Kudła B,

Keywords: nens, metastasis, hdf, stic, 4-dimensional sonography,

#1945 Metabolic Adaptation to Anti-Angiogenic Therapy

Introduction: Although anti-angiogenic inhibition (AI) therapy has demonstrable efficacy in mouse models of cancer and in certain types of human cancer, responses are typically transitory, followed by resumption of malignant progression that limits survival benefit. Unconventional modes of evasive/adaptive resistance underlay the eventual failures of anti-angiogenic therapy. Functionally established resistance mechanisms include revascularization mediated by alternative pro-angiogenic signals, protection by peri-vascular macrophages and monocytes to induce an immunosuppressive microenvironment, and normal vessel cooption via heightened local invasion and distant metastasis. All three mechanisms have been documented in the prototypical RIP-Tag2 mouse model of multistep tumorigenesis, in which the angiogenic switch is a discrete step in the pathway to invasive pancreatic neuroendocrine cancer.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Allen E

Authors: Allen E,

Keywords: AI/mTOR,