Grading diagnostic accuracy of EUS Tissue Acquisition in pancreatic neuroendocrine tumors: A systematic review and meta-analysis

#3586

Introduction: Pancreatic neuroendocrine neoplasms (PanNENs), are a form of neoplasms arising from cells of the endocrine and nervous systems. Grading (G) is one of the most important decisional factor for therapy as is associated with prognosis, overall survival and disease free survival decrease. Endoscopic ultrasound fine needle-aspiration/biopsy (EUS-FNA/B) is the gold standard for diagnosing PanNENs and Ki67 evaluation, but data regarding accuracy and concordance with post-surgical histological examination are scanty and heterogeneous.

Aim(s): Evaluate concordance rate of Ki67 grading between EUS FNA/FNB and surgical pathology specimens and diagnostic accuracy of EUS tissue acquition in PanNENs and c

Materials and methods: The MEDLINE, SCOPUS, and EMBASE databases were searched from inception to August 2021 to identify studies reporting data on grading concordance rate between EUS FNA/B samples and surgical specimens in patients with PanNENs.

Conference:

Presenting Author:

Authors: Tacelli M, Bina N, Crinò S, Facciorusso A, Barresi L,

Keywords: endoscopic ultrasound, net, ki67, who, misclassification,