A Case with Multiple Neuroendocrine Tumors Abstract #1751

Introduction: Multiple endocrine neoplasia (MEN) is characterized by the occurrence of tumours involving two or more endocrine glands. MEN 1 is characterized by parathyroid adenoma, pancreaticoduodenal neuroendocrine tumors (PNTs), and pituitary adenomas.
Aim(s): We report the case of a 28-year-old woman hospitalized for weight loss and diarrhea.
Materials and methods: A CT scan was performed and showed 2 small lesions in the pancreas, a mass in the left lung and multiple cystic tumours in the liver. The patient underwent endoscopic ultrasound with biopsies of the pancreatic lesions which showed well differentiated neuroendocrine tumour. An Octreo PET was positive for the pancreas tumours and for liver lesions. PET CT scan was only positive for the lung mass and the liver metastases. High level of Chromogranin A was found (518 mcg/l) as well as Urinary 5HIAA (90mg/24h). Transthoracic biopsy of the lung mass demonstrated a well differentiated neuroendocrine tumor. We started subcutaneous somatostatin analogs which improved the diarrhea. A CT scan performed after 2 months showed partial response. The patient also had parathyroid adenoma with primary hyperparathyroidism. Hypophysis imaging was negative.
Conference: 14th Annual ENETS conference 2017 (2017)
Category: Clinical cases/reports
Presenting Author: MD Alexandre Dermine

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