A Kinomic Approach to Identify Signaling Proteins Involved in Drug Resistance in GastroEnteroPancreatic Neuroendocrine Tumors Abstract #1739

Introduction: Most of the current therapeutic strategies used for neuroendocrine tumors (NETs) result in tumour growth stabilization, eventually followed by tumour progression. Thus, despite their original characteristics, NETs exhibit similar resistance features to treatments than other more common tumours.
Aim(s): We aim at identifying signaling partners responsible of acquired resistance to treatments in order to develop drug combinations to prevent resistance occurence.
Materials and methods: We engineered NETs cell lines, BON-1 and QGP-1, resistant to a chemotherapeutic agent, Oxaliplatin, and to an mTor inhibitor, Everolimus, by chronically exposing them to the drugs. We are using microarray-based kinomics to obtain highthroughput kinase activity profiles from drug sensitive vs resistant cells.
Conference: 14th Annual ENETS conference (2017)
Category: Basic Science - Signaling pathways, receptors, biomarkers
Presenting Author: Dr David Romano

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