Introduction: Increased cyclin dependent kinases 4, 6 (cdk 4/6) activity is noted in the majority of well differentiated foregut neuroendocrine tumors (fNETs) due to mutations in MENIN and other aberrations. These tumors also have preserved Rb function making cdk 4/6 inhibitors attractive agents for therapy.
Aim(s): To evaluate the activity of the oral cdk 4/6 inhibitor, ribociclib (R) in fNETs
To evaluate the pharmacodynamic activity of R in paired biopsies at baseline and cycle (c) 2 day 1
Materials and methods: In this single institution study, 20 patients (pts) with advanced, progressive fNETs were treated with R 600 mg by mouth daily for 3 weeks (w) and off for 1w in 4w cycles (c). Pancreatic NET (pNET) patients were required to have progression on prior therapy. Re-staging scans were obtained every 3c.
Conference: 15th Annual ENETS conference 2018 (2018)
Category: Medical treatment -Targeted therapies
Presenting Author: Assistant Profes Arvind Dasari
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