Action of the Hypothalamic Proline-Rich Peptide During Vestibular Compensation Following Unilateral Labyrinthectomy

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Introduction: There are uncovered mechanisms of the vestibular compensation (VC), following unilateral labyrinthectomy (UL). We consider the hypothalamic proline-rich peptide (PRP-1) action on Deiters’ lateral vestibular nucleus (LVN) neurons upon dynamics of recovery after UL was carried out.

Aim(s): Early and late tetanic, post-tetanic potentiation and depression of neurons to bilateral high frequency stimulation of hypothalamic supraoptic and paraventricualar nuclei was studied. The analysis of spike activity by on-line selection and software package was produced.

Materials and methods: The complex averaged peri event time and frequency histograms were constructed. The increase of inhibitory and excitatory reactions of Deiters’ neurons at early stage of VC following PRP-1 injection reaching the norm at late stage was revealed. Moreover, the shifts of post-stimulus activation are relatively more expressive when high frequency stimulation by 100Hz.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Hambardzumyan L,

Keywords: Deiters’ neurons, hypothalamic proline-rich peptide,